Influence of different types of dialysis membranes on parameters of chronic inflammatio

Completed

• Conditions: Urological and Genital Diseases; Renal disease; End-stage renal disease

• Registration Number: ISRCTN47228763
• Lead Sponsor: Gambro SAS (France)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-03-24
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

1. Medically stable end-stage renal disease patients on hemodialysis for 6 months or more
2. Age =18 years
3. C-reactive protein between 5 and 50 mg/l maximum one week before inclusion
4. Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) serologies negative
5. Not under guardianship
6. AgHbs negative
7. Absence of vascular access thrombosis
8. Absence of clinically identifiable cause of chronic inflammation
9. Treatment in a dialysis unit providing water quality according to the European Pharmacopoeia
10. Statin medication allowed, but no introduction or modification during the study
11. Hemodialysis blood flow rates between 200 and 500 ml/min possible
12. Dialysis frequency 3-4 per week

Exclusion Criteria

1. Age >75 years
2. Known pregnancy
3. Severe comorbidities with life expectancy <1 year
4. Cancer except skin cancer
5. Severe digestive pathologies
6. Chronic inflammatory diseases
7. Medication interfering with nutritional or inflammatory status
8. Treatment or intention to treat with immunosuppressive medication
9. Dialysis dose Kt/V <1.2, and dialysis time <10 hours per week
10. Treatment with hemofiltration or hemodiafiltration
11. Participation in another study during the preceding 30 days
12. Physically or mentally disabled patients

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma concentration of C-reactive protein

Secondary Outcome Measures

Name	Time	Method
Advanced glycation end products, carboxymethyl lysine, asymmetric dimethyl arginine, fibrinogen, albumin and prealbumin, phosphate