An Eye-tracking Study to Investigate Oxytocin Effect on Attention Inhibition
Overview
- Phase
- Not Applicable
- Intervention
- oxytocin treatment
- Conditions
- Healthy
- Sponsor
- University of Electronic Science and Technology of China
- Enrollment
- 71
- Locations
- 1
- Primary Endpoint
- emotion-specific saccade latencies
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Effects of intranasal oxytocin (24IU) on cognitive control of attention
Detailed Description
The cognitive control of attention towards neutral and emotional stimuli represents a key functional domain and disruptions in this domain have been associated with a range of psychiatric disorders. Saccadic eye movement tasks have been used to assess individual differences in the cognitive control of attention and alterations in psychiatric disorders. Recent evidence suggests that the hypothalamic neuropeptide Oxytocin (OXT) may modulate attention allocation and regulation. To this end the present randomized between-subject placebo-controlled experiment examined whether intranasal OXT modulates behavior in an eye-tracking saccade / anti-saccade paradigm in healthy male subjects. The paradigm used non-social (neutral shape) as well as social (happy, sad, angry, fear, and neutral faces) stimuli to explore emotion-specific effects of OXT.
Investigators
Benjamin Becker
Professor
University of Electronic Science and Technology of China
Eligibility Criteria
Inclusion Criteria
- •Male, healthy participants
- •Non smokers
Exclusion Criteria
- •Previous or current medical, psychiatric, neurological disorder
- •Regular medication
- •Use of any psychoactive substances in the 24 hours before experiment
- •Contra-indications for oxytocin
- •Contra-indications for eye-tracking data acquisition
Arms & Interventions
oxytocin group
Intervention: oxytocin treatment
placebo group
Intervention: placebo treatment
Outcomes
Primary Outcomes
emotion-specific saccade latencies
Time Frame: 45 minutes - 100 minutes after treatment
comparison between emotion-specific saccade latencies between the treatment groups (in milliseconds)
emotion-specific error rates
Time Frame: 45 minutes - 100 minutes after treatment
comparison between the emotion-specific ratio of unsuccessful anti-saccades between the treatment groups.