The Modulatory Effect of Oxytocin on Attentional Processing of Emotional Faces
Overview
- Phase
- Not Applicable
- Intervention
- oxytocin treatment
- Conditions
- Healthy
- Sponsor
- University of Electronic Science and Technology of China
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Response time in reponse to different emotional face targets.
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
To investigate whether intranasal oxytocin (24IU) treatment has a regulatory effect on attentional processing of emotional faces.
Detailed Description
In a placebo-controlled double-blind between-subject design experiment, investigators plan to investigate the effect of oxytocin treatment on attentional processing of emotional faces. Subjects complete questionnaires in Chinese versions before treatment administration, including the Beck Depression Inventory, Autism Spectrum Quotient , Trait Anxiety Inventory, Toronto Alexithymia Scale, Multidimentional Assessment of Interoceptive Awareness. This experiment consists of two tasks including Emotional Face Cue-target Task and Visual Search Task. In the first task, subjects need to make a response to judge the position of target after a cue-target is presented. In the second task, subjects are asked to search the target "U" or inverted "U" placed on the nose of emotional/neutral faces and make an choices based on their oorientation. During these phases, subjects' response accuracy, response time and electrophysiological activity (ERP) are recorded.
Investigators
Shuxia Yao
Associate Professor
University of Electronic Science and Technology of China
Eligibility Criteria
Inclusion Criteria
- •Healthy subjects without past or current psychiatric or neurological disorders.
Exclusion Criteria
- •history of head injury
- •medical or psychiatric illness
Arms & Interventions
oxytocin group
male subjects with oxytocin treatment
Intervention: oxytocin treatment
placebo group
male subjects with placebo treatment
Intervention: placebo treatment
Outcomes
Primary Outcomes
Response time in reponse to different emotional face targets.
Time Frame: 1 hour
Response time in discriminating which side (left or right) the emotional face target appear.
N2pc
Time Frame: 1 hour
N2pc is an enhanced negative event-related potential typically elicited at posterior electrodes (e.g., PO7 and PO8) contralateral to the target presented among distractors between 180 and 300 ms after the onset of stimuli. display.
Secondary Outcomes
- Response accuracy in response to different emotional face targets.(1 hour)