Oxytocin's Effects on Face Attentional Processing

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Drug: oxytocin treatment; Drug: placebo treatment

• Registration Number: NCT04413786
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

To investigate whether intranasal oxytocin (24IU) treatment has a regulatory effect on attentional processing of emotional faces.

Detailed Description

In a placebo-controlled double-blind between-subject design experiment, investigators plan to investigate the effect of oxytocin treatment on attentional processing of emotional faces. Subjects complete questionnaires in Chinese versions before treatment administration, including the Beck Depression Inventory, Autism Spectrum Quotient , Trait Anxiety Inventory, Toronto Alexithymia Scale, Multidimentional Assessment of Interoceptive Awareness. This experiment consists of two tasks including Emotional Face Cue-target Task and Visual Search Task. In the first task, subjects need to make a response to judge the position of target after a cue-target is presented. In the second task, subjects are asked to search the target "U" or inverted "U" placed on the nose of emotional/neutral faces and make an choices based on their oorientation. During these phases, subjects' response accuracy, response time and electrophysiological activity (ERP) are recorded.

Study Timeline

• Study Start: 2019-10-14
• Study First Submitted: 2020-05-25
• Study First Submitted QC: 2020-05-28
• Study First Posted: 2020-06-04
• Primary Completion: 2021-12-16
• Study Completion: 2021-12-26
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-08
• Last Update Posted: 2022-02-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• Healthy subjects without past or current psychiatric or neurological disorders.

Exclusion Criteria

• history of head injury
• medical or psychiatric illness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
oxytocin group	oxytocin treatment	male subjects with oxytocin treatment
placebo group	placebo treatment	male subjects with placebo treatment

Primary Outcome Measures

Name	Time	Method
Response time in reponse to different emotional face targets.	1 hour	Response time in discriminating which side (left or right) the emotional face target appear.
N2pc	1 hour	N2pc is an enhanced negative event-related potential typically elicited at posterior electrodes (e.g., PO7 and PO8) contralateral to the target presented among distractors between 180 and 300 ms after the onset of stimuli.; display.

Secondary Outcome Measures

Name	Time	Method
Response accuracy in response to different emotional face targets.	1 hour	Response accuracy is caculated by the precentage of correct responses among the total responses in discriminating the position (left or right side) of different face conditions.

Trial Locations

Locations (1)

School of life science and technology, University of Electronic Science and Technology of China; 🇨🇳 Chengdu, Sichuan, China