Thrombin generation after abrupt cessation versus weaning over eight hours of continuous infusion of unfractionated heparin in intensive care unit patients after discontinuation of continuous venovenous haemofiltratio

Completed

• Conditions: Venovenous haemofiltration; Haematological Disorders; Haematological procedures

• Registration Number: ISRCTN33216118
• Lead Sponsor: Academic Medical Centre (AMC) (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-11-22
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

1. Patients scheduled to stop treatment with continuous venovenous haemofiltration (CVVH) because they no longer require it (physicians discretion/local protocol)
2. Age more than 18 years
3. At least 48 hours of CVVH treatment with concomitant continuous infusion of unfractionated heparin (UFH)
4. At least 36 hours of continuous UFH infusion in the last 48 hours prior to inclusion

Exclusion Criteria

1. Patients with known coagulation disorders
2. Patients receiving any anti-coagulant treatment for reasons other than CVVH

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thrombin-antithrombin complexes (TATc)

Secondary Outcome Measures

Name	Time	Method
1. Activated partial thromboplastin time (aPTT)<br>2. Anti-factor Xa (anti-Xa)<br>3. Factor VII/VIIa<br>4. Tissue factor (TF)<br>5. Tissue factor pathway inhibitor (TFPI)-antigen<br>6. TFPI activity<br>7. Protein C/activated protein C (aPC)<br>8. Activated protein C sensitivity ratio (aPC-sr)<br>9. Prothrombin fragment 1.2, ETP (endogenous thrombin potential)<br>10. Fibrin monomers<br>11. Soluble thrombomodulin<br>12. Plasmin-a2-anti-plasmin complexes (PAPc)<br>13. Plasminogen-activator inhibitor (PAI)