Remote Ischemic Preconditioning in Aortic Valve Surgery
Not Applicable
Completed
- Conditions
- Aortic Valve Stenosis
- Interventions
- Procedure: ControlProcedure: Remote ischemic preconditioning
- Registration Number
- NCT01390129
- Lead Sponsor
- University Hospital, Angers
- Brief Summary
RIP-VALVE is a randomized, single blinded study that will test the hypothesis that remote ischemic preconditioning initiated before surgery reduces post-operative myocardial damage in aortic valve surgery. Infarct size will be determined by 72 hours area under curve of troponin-I.
- Detailed Description
The hypothesis tested in this research proposal is that remote ischemic preconditioning initiated immediately before aortic valve surgery reduces myocardial damage related to surgery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Age > 18
- Aortic valve surgery for aortic stenosis
- Written informed consent
Exclusion Criteria
- Aortic valve surgery combined with CABG or an other valve surgery
- Previous Q-wave myocardial infarction or previous coronary artery bypass graft
- Coronary artery stenosis >70%
- Ejection fraction <35%
- Surgery performed in emergency
- Nicorandil ou metformin treatment within 8 days before surgery
- Patient refusal / patient not having provided written informed consent.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control Control - Remote ischemic preconditioning Remote ischemic preconditioning -
- Primary Outcome Measures
Name Time Method Infarct size 72 hours Infarct size as assessed by 72 hours area under curve serum troponin-I
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital, Angers
🇫🇷Angers, France