Effect of co-administration of HMG-CoA Reductase Inhibitor on the endothelial dysfunction after continuous treatment of nitroglycerin in Japanese volunteers with aldehyde dehydrogenase2 Glu487Lys genotypes: randomized crossover trial
Not Applicable
- Conditions
- angina pectoris
- Registration Number
- JPRN-UMIN000013382
- Lead Sponsor
- Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu Univertisy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
Not provided
Exclusion Criteria
1. History of cardiovascular disease 2. Severe hepatic dysfunction 3. Severe renal dysfunction 4. Woman who is pregnant or possibly be pregnant 5. History of severe allergy or allergic reaction to the drugs which are used in the present study 6. History of heart disease, glaucoma, peptic ulcer and aspirin-induced asthma 7. On medical treatment (exclude NSAIDs and sleeping pills taken as needed) 8. On medical treatment of phosphodiesterase 5 9. Systolic blood pressure <90 mmHg 10. Body weight <40 kg or >90 kg 11. Not appropriate to this study by other reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method