Analyzes of Hemorrhagic Obstetric Patients Whose Were Used Fibrinogen

Completed

• Conditions: Hemorrhage

• Registration Number: NCT03723200
• Lead Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Brief Summary

The files of hemorrhagic obstetric patients undergoing surgery and followed in the intensive care unit and using Fibrinogen and blood products were included in the study between January 2015- September 2018 at the Anesthesiology and Reanimation Clinic of SBU Kanuni Sultan Süleyman Training and Research Hospital. Patients under 18 years of age were excluded from the study. In this study, ages, operation types, number of blood and products, the amount of fibrinogen, the results of the hemogram and bleeding parameters, the levels of fibrinogen, the duration of hospital stay and the intensive care unit were recorded.

Detailed Description

Bleeding is an important event that threatens the patient's life. Too much blood and blood products can be used in massive bleeding. However, unwanted allergic reactions may occur in blood and blood product transfusions. Fibrinogen is the first coagulation factor in coagulopathy. Some studies have shown that when the fibrinogen level falls to \<150-200 mg / dl, the bleeding increases dramatically.

Study Timeline

• Status Verified: 2018-10
• Study Start: 2018-10-09
• Primary Completion: 2018-10-16
• Study Completion: 2018-10-24
• Study First Submitted: 2018-10-24
• Study First Submitted QC: 2018-10-25
• Last Update Submitted: 2018-10-26
• Study First Posted: 2018-10-29
• Last Update Posted: 2018-10-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 56

Inclusion Criteria

• Obstetric patients, underwent surgery and followed in ICU
• Used Fibrinogen and Blood products
• Over 18 years age

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Exclusion Criteria

• Under 18 years age
• Obstetric patients, underwent surgery but not used Fibrinogen and Blood products

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measurement of fibrinogen (mg/L)	24 hours	Significant independent predictor for evolution to severe PPH was plasma fibrinogen level.
Amount of blood products (unit)	24 hours	degree of hemorrhagie
Measurement of hemoglobin (g/dL)	24 hours	Postpartum hemorrhage (PPH) is a major contributor to maternal death and severe maternal morbidity
Amount of fibrinogen consantrates	24 hours	in order to avoid PPH

Secondary Outcome Measures

Name	Time	Method
Hospital stay days	24 hours	for the recovery time of patients

Trial Locations

Locations (1)

Kanuni Sultan Suleyman Education and Training Hospital; 🇹🇷 Istanbul, Kucukcekmece, Turkey