Comparison of Continuous Feeding and Sequential Feeding on Gut Microbiota and Metabolomics in Critically Ill Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Feeding Behavior
- Sponsor
- Qingdao University
- Enrollment
- 158
- Locations
- 1
- Primary Endpoint
- Shannon index
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Continuous feeding is the most popular enteral feeding mode in the ICU because of its lower nursing burden and theoretically better intestinal toleration. However, continuous feeding is nonphysiological. We proposed a feeding mode called sequential feeding, as it utilizes a combination of continuous feeding in the beginning, time-restricted feeding in the second stage, and oral feeding at last.
The gut microbiota plays a critical role in human health due to its many useful functions. Not only dietary structure but also eating mode (eating time for example) influenced the gut microbiota in a healthy population. Therefore, we think this new feeding mode, sequential feeding, also has different influences on gut microbiota and metabolomics in critically ill patients compared to continuous feeding.
Detailed Description
Nutrition is an important part of therapy for critically ill patients. Continuous feeding is the most popular enteral feeding mode in the ICU because of its lower nursing burden and theoretically better intestinal toleration. However, continuous feeding is nonphysiological. In our opinion, feeding mode should be changed according to gastrointestinal function and disease progression; one singe feeding mode is not always suitable for critically ill patients. We proposed a feeding mode called sequential feeding, as it utilizes a combination of continuous feeding in the beginning, time-restricted feeding in the second stage, and oral feeding at last. The gut microbiota plays a critical role in human health due to its many useful functions, such as metabolism, vitamin metabolism, and maintenance of the intestinal barrier and immune system. Not only dietary structure but also eating mode (eating time for example) influenced the gut microbiota in a healthy population. Therefore, we think this new feeding mode, sequential feeding, also has different influences on gut microbiota and metabolomics in critically ill patients compared to continuous feeding.
Investigators
Bo Yao,phD
Clinician of critical care medicine, principal investigator
Qingdao University
Eligibility Criteria
Inclusion Criteria
- •●Patients newly admitted to the ICU and fed through gastric tubes
Exclusion Criteria
- •Patients with the ability to eat orally at admission
- •Patients with diabetes or gastrointestinal disease
- •Patients who are unable to tolerate enteral feeding
- •An estimated feeding time of less than 7 days
Outcomes
Primary Outcomes
Shannon index
Time Frame: at the time point of 7th feeding day after achieving ≥80% of the nutrition target calories
Shannon index is a paramater of α diversity in gut microbiota Full-length 16S rRNA gene sequencing analysis using QIIME software
Secondary Outcomes
- bacteria bundance(at the time point of 7th feeding day after achieving ≥80% of the nutrition target calories)
- numbers of compounds(at the time point of 7th feeding day after achieving ≥80% of the nutrition target calories)