Study of Cognitive Function Before and After Coronary Angiography
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Karolinska Institutet
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Change in cognitive dysfunction from baseline to two days after coronary angiography
Study Overview
Brief Summary
The purpose of the study is to study if coronary angiography cause cognitive dysfunction.
Detailed Description
We have previously shown, using transcranial doppler, that coronary angiography cause cerebral microembolism. Cerebral microemboli were more common using the radial than femoral approach. Previously, cerebral microembolism has been associated with new cerebral lesions on MRI. The clinical significance of these new lesions is not determined. The primary aim of this pilot study is to see if coronary angiography cause cognitive dysfunction determined by the MoCA-test. A secondary aim is to relate cognitive dysfunction to cerebral microembolism measured by transcranial doppler. A third aim is to study potential differences between the femoral and radial approaches.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 35 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Elective coronary angiography irrespective of cause
Exclusion Criteria
- •Previous CABG, language problems, not willing to participate
Outcomes
Primary Outcomes
Change in cognitive dysfunction from baseline to two days after coronary angiography
Time Frame: Baseline and two days
The Montreal Cognitive Assesment test will be performed before, 2 and 30 days after coronary angiography
Secondary Outcomes
- Number of patients with cerebral microemboli(Baseline)
Investigators
Per Tornvall
Docent
Karolinska Institutet