Cognitive Function and Brain Connectivity in Carotid Artery Stenting Patients:a Rs-fMRI Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Montreal Cognitive Assessment, MOCA
研究概览
简要总结
This is a prospective study aimed to explore the changes of cognitive function after surgery for CAS and the correlation with brain connectivity, in order to look for the clinical biomarkers to predict the carotid stent implantation for patients which can effect the cognition
详细描述
Carotid artery stenting (CAS) can significantly decrease the incidence of ischemic stroke in patients with severe carotid artery stenosis has been confirmed in large randomized controlled studies (1, 2).Previous studies showed carotid artery stenosis is closely related to cognitive dysfunction, including asymptomatic carotid artery stenosis(≥70%).Cognitive impairment is one of the most serious problem facing the elderly. The impact on cognitive function in patients with CAS has been discussed by many researchers, however the effect still remained conflicting.
In past few years, several imaging techniques, such as resting-state functional MRI (R-fMRI), had been increasingly used to study cognitive impairment in humans. In this study, we evaluated the cognition performance in severe carotid artery stenosis patients undergoing CAS and explored the mechanisms underlying the cognition changes by the Rs-fMRI.
Inclusion criteria:
- age between 55 years and 80 years
- unilateral internal carotid artery stenotic degree ≥ 70%
- right-hand-dominant
- free of dementia, and depression
- modified Rankin Scale: 0 or 1
- education ≥6 years
- obtained written informed consent.
Exclusion criteria:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age between 55 years and 80 years
- •unilateral internal carotid artery stenotic degree ≥ 70%
- •right-hand-dominant
- •free of stroke, TIA, dementia, and depression
- •modified Rankin Scale: 0 or 1
- •education ≥6 years
- •obtained written informed consent.
排除标准
- •contralateral internal carotid artery stenosis ≥ 50%
- •posterior circulation diseases
- •MMSE < 26, which is a cut-off value for mild cognitive impairment
- •severe systemic diseases and neuropsychiatric diseases (such as congestive heart failure and history of stroke)
- •any contraindications for MRI scan (e.g., metal implants)
结局指标
主要结局
Montreal Cognitive Assessment, MOCA
时间窗: 3 months after CAS
use MOCA to assess the cognition after CAS
Mini-mental State Examination，MMSE
时间窗: 3 months after CAS
use MMSE to assess the cognition after CAS
次要结局
- Digit Symbol Test(3 months after CAS)
- Trail Making Test A/B(3 months after CAS)
- digital span test(3 months after CAS)