Interest of Eosinopia in the Diagnosis of Infection in the Emergency Department

• Conditions: Eosinopenia
• Interventions: Other: Diagnosis of bacterial infection

• Registration Number: NCT03467672
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Several studies have described the interest of eosinopenia as a marker of infection in internal medicine or in intensive care units. Eosinopenia is an inexpensive and easily accessible biological marker of sepsis. Retrospective work in the adult emergency departments of Strasbourg University Hospitals has shown the good specificity of this biological sign for the diagnosis of infection. Our work aims to confirm the results by a more meaningful study.

Main objective: Evaluation of the interest of eosinopenia in the diagnosis of bacterial infection in ED.

Methodology: inclusion of all patients with criteria for bacterial infection in ED, inclusion of an equivalent number of uninfected control patients.

Duration : 12 months Multicentric prospective study 6 centers : Strasbourg, Hôpital Nord Franche comté, Sélestat, Wissembourg, Colmar, Mulhouse

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-02-12
• Study First Submitted QC: 2018-03-15
• Study First Posted: 2018-03-16
• Study Start: 2018-03-23
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-29
• Last Update Posted: 2019-05-01
• Primary Completion: 2020-03
• Study Completion: 2020-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• major patient
• patient suspected of infection and benefiting from the routine practice of NFS, whatever the indication during his / her visit to the emergency room.
• patient with or without criteria for bacterial infection
• patient affiliated to a social security scheme
• patient (or legal representative) who has agreed to participate in the study

Exclusion Criteria

• anti tumor chemotherapy
• immunosuppressive treatment
• corticotherapy
• antibiotherapy in progress
• malignant hemopathy
• evolutionary cancer
• refusal to participate in the study
• subjects under safeguard of justice
• subject under guardianship or curatorship

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control group	Diagnosis of bacterial infection	-
Infected patients	Diagnosis of bacterial infection	-

Primary Outcome Measures

Name	Time	Method
eosinopenia as a sepsis marker	102 month	Evaluation of the interest of eosinopenia in the diagnosis of infectious states in emergencies.

Trial Locations

Locations (6)

CH de MULHOUSE; 🇫🇷 Mulhouse, France

Ch Wissembourg; 🇫🇷 Wissembourg, France

Ch Selestat; 🇫🇷 Sélestat, France

CH Nord Franche comte; 🇫🇷 Trévenans, France

Les Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg, France

CH de COLMAR; 🇫🇷 Colmar, France