Probing and Modulating Motor Imagery Capacities in Aphantasia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Gains in motor performance following mental training
研究概览
简要总结
The present study aims to characterize and modulate motor imagery abilities in individuals with aphantasia. The investigators will characterize the neurophysiological and physiological underpinnings of mental imagery abilities in participants with aphantasia by investigating several indices of motor imagery abilities and comparing them to participants with typical mental imagery abilities. The investigators will investigate whether non-invasive brain stimulation applied to the primary motor cortex improves mental imagery abilities in participants with aphantasia.
详细描述
The investigators will recruit 20 participants with aphantasia and 20 participants with typical mental imagery capacities (no-aphantasia groups). Participants in both groups will complete a 3-hour visit for inclusion and baseline measurements (Visit 1) which will include neurophysiological, autonomic nervous system, cognitive and behavioral measures.
Participants in the aphantasia group will complete 2 additional visits to receive active and sham tDCS sessions (Visit 2 and 3), according to a randomized, double-blind, sham-controlled, crossover design. Mental training will be done concurrently with tDCS using a sequential finger tapping-task (Truong et al., 2022). Participants will receive the instructions of trying to imagine themselves performing the motor task, by feeling their fingers moving as if they were actually moving it (kinesthetic modality of motor imagery).
Visits will be separated by at least 7 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Participants and experimenters (including tDCS operator) will not be informed about the nature (active or placebo) of the stimulation they will receive
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For the aphantasia group only: congenital aphantasia defined as a life-long inability to generate mental imagery (confirmed by a total score of 32 or less on the VVIQ, which is the gold standard questionnaire for aphantasia)
- •For the no-aphantasia group only: typical mental imagery capacities (confirmed by a total score of more than 32 on the VVIQ)
- •Covered by public health insurance
- •Understanding the French language
- •Signed written informed consent after being informed about the study
排除标准
- •Presence or history of a somatic, neurologic, or mental illness
- •Actual pain or musculoskeletal disorders at the upper limb
- •Having a regular musical activity (more than once a week) because of high manual dexterity
- •Contraindication for noninvasive brain stimulation including the presence of ferromagnetic or magnetic sensitive metal objects implanted in the head or in close proximity (e.g., brain stent, clip, cochlear implants, or stimulator)
- •Pregnancy (controlled by urine pregnancy test in females without reported contraception)
- •Active seizure disorder or history of seizures
- •Participants under curatorship/guardianship
结局指标
主要结局
Gains in motor performance following mental training
时间窗: 2 times: immediately before tDCS (baseline) and immediately after tDCS
Gains in motor performance following mental training combined with tDCS will be measured using a sequential finger tapping-task. Gains following training will be expressed as a percentage of the baseline performance.
次要结局
- Performance of time-to-contact estimation(1 time at baseline, in both groups)
- Heart rate variability(through study completion, an average of 1 month)
- Skin conductance(through study completion, an average of 1 month)
- Source monitoring performance(1 time at baseline, in both groups)
- Motor corticospinal excitability at rest and during kinesthetic motor imagery(1 time at baseline (Visit 1), in both groups)
- Implicit motor imagery capacities(1 time at baseline, in both groups)
- Mental imagery abilities(1 time at baseline, in both groups)