Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- renal biomarker levels
研究概览
简要总结
The investigators objective is to assess the utility of renal biomarkers in predicting renal recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). Tissue biomarkers of renal injury may provide a real-time indication of renal function and the likelihood of renal recovery in patients having cardiogenic shock and requiring VA-ECMO. In these patients, traditional markers of kidney function (urine output and serum Creatinine level) do not accurately represent renal function.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age more than 18 years
- •refractory or advanced cardiogenic shock prior to institution of VA-ECMO
排除标准
- •History of chronic kidney disease prior to cardiogenic shock, as defined by estimated glomerular filtration rate (GFR) less than 60 mL per min
- •Cognitive impairment
- •Pregnant women
- •patient or surrogate is not fluent in English
- •Long-term immunosuppression
结局指标
主要结局
renal biomarker levels
时间窗: through VA-ECMO decannulation, an average of 3 weeks
need for continuous renal replacement therapy at hospital discharge (Yes/No)
时间窗: measured at hospital discharge, an average of 2-3 months following initial hospital admission
The need for continuous renal replacement therapy at hospital discharge will be assessed using hospital medical records
次要结局
未报告次要终点
研究者
Anthony Bonavia
Assistant Professor
Penn State Health Milton S Hershey Medical Center