Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Milton S. Hershey Medical Center
- Enrollment
- 2
- Locations
- 1
- Primary Endpoint
- renal biomarker levels
- Status
- Terminated
- Last Updated
- last year
Overview
Brief Summary
The investigators objective is to assess the utility of renal biomarkers in predicting renal recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). Tissue biomarkers of renal injury may provide a real-time indication of renal function and the likelihood of renal recovery in patients having cardiogenic shock and requiring VA-ECMO. In these patients, traditional markers of kidney function (urine output and serum Creatinine level) do not accurately represent renal function.
Investigators
Anthony Bonavia
Assistant Professor
Penn State Health Milton S Hershey Medical Center
Eligibility Criteria
Inclusion Criteria
- •age more than 18 years
- •refractory or advanced cardiogenic shock prior to institution of VA-ECMO
Exclusion Criteria
- •History of chronic kidney disease prior to cardiogenic shock, as defined by estimated glomerular filtration rate (GFR) less than 60 mL per min
- •Cognitive impairment
- •Pregnant women
- •patient or surrogate is not fluent in English
- •Long-term immunosuppression
Outcomes
Primary Outcomes
renal biomarker levels
Time Frame: through VA-ECMO decannulation, an average of 3 weeks
need for continuous renal replacement therapy at hospital discharge (Yes/No)
Time Frame: measured at hospital discharge, an average of 2-3 months following initial hospital admission
The need for continuous renal replacement therapy at hospital discharge will be assessed using hospital medical records