Major depression as a metabolic disorder: The role of oxygen homeostasis and mitochondrial bioenergetics in depression etiology and therapy
- Conditions
- F32F33Depressive episodeRecurrent depressive disorder
- Registration Number
- DRKS00025457
- Lead Sponsor
- Department of Clinical and Biological Psychology, Ulm University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 300
A diagnosis of major depressive disorder according to DSM-5; accepted psychological comorbidities: anxiety disorders, and somatoform disorders. Stable medication is permitted.
High suicidality, PTSD and complex PTSD, Borderline personality disorder, eating disorders, obsessive compulsive disorder, bipolar disorder, schizophrenia or a history of psychotic disorders, acute substance-related disorder, organic mental disorder, pregnancy and nursing, neurological diseases, immunological and endocrine disorders, autoimmune diseases such as chronic viral infections, rheumatoid arthritis, cardiovascular comorbidities, cancer, chronic obstructive pulmonary diseases, Body Mass Index (BMI) > 30, usage of certain intrauterine devices (eg. Mirena)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcomes will be measured using the whole blood and immune cells of the participants at the beginning of each time point. ATP-turnover-related respiration, uncoupled respiration, and routine respiration will be measured from the immune cells, using high resolution respirometry. Mitochondrial density of the immune cells will be determined spectrophotometrically by measuring citrate syntase activity of the immune cells. Hemoglobin concentration and erythrocyte cell number per ml will be measured in whole blood.
- Secondary Outcome Measures
Name Time Method Secondary outcomes will be measured using the whole blood and immune cells of the participants at the beginning of each time point. <br>Oxygen-homeostasis-related parameters will be determined either from whole blood with a blood gas analyzer (glucose, lactate, pH, O2 and CO2 partial pressure), or from serum by clinical routine measurements (free iron, iron proteins, bilirubin), or with pulse oximeter (O2 saturation) and ear thermometer (body temperature). <br>Inflammation parameters (CRP, IL-1beta, IL-2, IL-6, IL-10, TNF-alpha) will be determined from serum via enzyme-linked immunosorbent assay.<br>Oxidative stress parameters will be determined from whole blood via Electron Spin Resonance (Reactive Oxygen Species) and indirectly from serum via enzyme-linked immunosorbent assay (8OH-dG, 8-isoprostane).