Yoga for People Suffering from Drug Addictio

Phase 1

Conditions: Health Condition 1: F10-F19- Mental and behavioral disorders due to psychoactive substance use

Registration Number: CTRI/2019/01/017218

Lead Sponsor: Department of Science and Technology SATYAM Scheme

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

They will be recruited from Centre for Addiction Medicine, National Institute of Mental Health And Neurosciences (NIMHANS) from the outpatient department and inpatient department.

3.Diagnosed with Opioid dependence syndrome (prescription and street Opioids) as per ICD-10

4.Patients stabilized by medications for withdrawal symptoms

5.Willingness to provide written informed consent

Exclusion Criteria

1.H/o or current medical illness that may significantly influence CNS function or structure

2.Patients with intractable pain due to other diseases

3.Patients on prescribed opioids for pain of other medical conditions

4.General impaired intellectual functioning (Mini-Mental Status Exam, MMSE below24 )

5.Contraindication to MRI like metal implants or paramagnetic objects within the body or claustrophobia

6.Past history of head injury

7.Concomitant severe medical conditions

8.Those with co-morbid alcohol/BZD/Cannabis/Multiple substance dependence except nicotine

9.H/o receiving specific Yoga practice for Opioid dependence in the past

10.Pregnancy or post-partum

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma endorphin levels and Buprenorphine dosage requirementTimepoint: At 0, immediate after 1st yoga session, after 2 weeks and at 3 months

Secondary Outcome Measures

Name	Time	Method
<br/ ><br>Various psychometric tests which assess psychological state, craving, withdrawal symptoms, quality of life, suicidality etc. <br/ ><br>Biological Assessments <br/ ><br> Other lab assessments: Complete blood count; liver function (AST, ALT, LDH, bilirubin); fMRI acquisition and analysis: <br/ ><br>Relapse rate and number of hospitalizations will also be assessed <br/ ><br>Timepoint: At 0, immediate after 1st yoga session, after 2 weeks and at 3 months