A randomized controlled trial of patients with obsessive-compulsive disorder: A functional magnetic resonance imaging study

Not Applicable

• Conditions: obsessive-compulsive disorder(OCD)

• Registration Number: JPRN-UMIN000001726
• Lead Sponsor: Kyushu University

Brief Summary

akao T, Nakagawa A, Yoshiura T, Nakatani E, Nabeyama M, Yoshizato C, et al. (2005): Brain activation of patients with obsessive-compulsive disorder during neuropsychological and symptom provocation tasks before and after symptom improvement: a functional magnetic resonance imaging study. Biological psychiatry. 57:901-910. Nakao T, Nakagawa A, Yoshiura T, Nakatani E, Nabeyama M, Yoshizato C, et al. (2005): A functional MRI comparison of patients with obsessive-compulsive disorder and normal controls during a Chinese character Stroop task. Psychiatry research. 139:101-114. Nakatani E, Nakagawa A, Nakao T, Yoshizato C, Nabeyama M, Kudo A, et al. (2005): A randomized controlled trial of Japanese patients with obsessive-compulsive disorder--effectiveness of behavior therapy and fluvoxamine. Psychotherapy and psychosomatics. 74:269-276. Nabeyama M, Nakagawa A, Yoshiura T, Nakao T, Nakatani E, Togao O, et al. (2008): Functional MRI study of brain activation alterations in patients with obsessive-compulsive disorder after symptom improvement. Psychiatry research. 163:236-247.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2007-08-01
• Study Start: 2009-02-22
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Not provided

Exclusion Criteria

comorbid axis I diagnosis neurological disorder head injury serious medical condition history of drug/alcohol addiction a total y-BOCS score lower than 16 a HDRS score more than 18 points a total IQ of less than 80

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Yale-Brown Obsessive Compulsive Scale (Y-BOCS) (after the 12-week treatment) functional activation maps (before and after treatment) Neuropsychological tests (attention, executive function, memory)

Secondary Outcome Measures

Name	Time	Method
Hamilton Depressive Rating Scale (HDRS) State-Trait Anxiety Inventory (STAI) (after the 12-week treatment)