Effect of Low Glycemic Index Diet on Body Composition and Mechanism of Obese Women

Not Applicable

• Conditions: Obesity
• Interventions: Other: Low glycemic index diet

• Registration Number: NCT01255228
• Lead Sponsor: Taipei Medical University WanFang Hospital

Brief Summary

Excessive body weight and obesity have reached epidemic proportions over the last few decades, which may cause many chronic diseases. Maintaining a healthy life style could decrease the risk for obesity, metabolic syndrome and cardiovascular disease. The study aimed to evaluate long-term low glycemic index (GI) diet intervention on lipid profile, body composition and the mechanism of obese women. The pilot study will recruit twenty healthy subjects, and served test food to determine low GI food. In the experiment period, twenty women age from 20-50 years will be recruited. To be included in the study, subjects should have a BMI above 24 kg/m2, or the either one (fat mass ≧ 30% or waistline \> 80 cm). Before dietary intervention, participants will receive food choice table and dietary questionnaires to record their dietary intake.

The study will be a randomized, crossover, controlled clinical trails. The experiment period have six weeks, each participants will provide low GI diet (lunch and dinner). On the 0, 3, 6 week, subjects will measurement their body composition (body weight, body mass, waist and hip circumferences) and collect fasting blood samples to analysis the lipid profile, free fatty acid, blood sugar, insulin, adiponectin, leptin and fatty acid synthesis enzymes. Statistical analysis will be performed by paired t-test. The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05
• Study First Submitted: 2010-11-18
• Status Verified: 2010-12
• Study First Submitted QC: 2010-12-05
• Last Update Submitted: 2010-12-05
• Study First Posted: 2010-12-07
• Last Update Posted: 2010-12-07
• Primary Completion: 2011-02
• Study Completion: 2011-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

• BMI above 24 kg/m2, or the either one ( fat mass ≧ 30% or waistline > 80 cm )

Exclusion Criteria

• Cardiovascular disease
• type 2 diabetes mellitus or impaired glucose tolerance
• serious liver or renal disease, gastro-intestinal disease
• proceed serious diet control for formerly three months
• take any supplemental food products or medications known to influence lipid or carbohydrate metabolism

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low glycemic index diet	Low glycemic index diet	The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women
diet intervention	Low glycemic index diet	The study expect that long-term low GI diet intervention have beneficial effects on regulate body composition of obese women

Primary Outcome Measures

Name	Time	Method
the effect of body composition ( body weight,body mass,waist and hip circumferences )	6 week

Trial Locations

Locations (1)

Taipei Medical University; 🇨🇳 Taipei, Taiwan