Study of TMS for enhancing recovery of function after acute stroke. (TRYST)
- Conditions
- Health Condition 1: G819- Hemiplegia, unspecified
- Registration Number
- CTRI/2020/02/023487
- Lead Sponsor
- Investigator initiated
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. First episode of acute hemispheric stroke (infarct or bleed) as established on neuroimaging
2. Age 18 - 80 years
3. Day 3 â?? 15 from onset of stroke symptoms,
4. NIH arm motor score >1
5. Stable GCS greater than or equal to 8 and off ventilator for 48 hours
1 Patients with major cognitive deficits/spasticity / contracture/limb deformities interfering with study participation.
2. Epilepsy, psychosis, delirium.
3. Patients who received Intravenous or Intra-arterial tissue plasminogen activator or thrombectomy
4. Concomitant acute Myocardial Infarction, pulmonary embolism or Deep Venous Thrombosis
5. Hemodynamic instability
6. Major cardiac, renal, hepatic or pulmonary dysfunction
7. Uncontrolled sepsis
8. Trauma-orthopedic injury that limits the range of motion of the upper limb
9. Contraindications to TMS like intracranial metallic implants, cardiac implants, pacemakers
10. Pregnancy or likely to become pregnant during the study period.
11. Patients with stroke associated with CNS infections, HIV, malignancy, haemopoetic disorders
12. Premorbid MRS score- greater than 2
13. Not willing to consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement in FMA-UE(Fugl Meyer Assessment-Upper extremity) scoreTimepoint: 3 months
- Secondary Outcome Measures
Name Time Method MAS (modified ashworth score), ARAT (action research arm test) and MRS (modified rankin scores)Timepoint: 3 months