Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study
Overview
- Phase
- N/A
- Intervention
- Cardiac MRI
- Conditions
- Left Ventricular Systolic Dysfunction
- Sponsor
- Mayo Clinic
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Recruitment Rate
- Status
- Recruiting
- Last Updated
- 2 months ago
Overview
Brief Summary
The purpose of this research is to determine the feasibility of a larger, future study proposing a multimodal approach using cardiac CT and MRI to assess the risk of developing left ventricular (LV) systolic dysfunction in patients with mitral regurgitation (MR).
Investigators
Alex K. Bratt
Division Chair of Thoracic Radiology
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •Age \>= 18
- •Male or Female
- •A diagnosis of severe chronic primary mitral regurgitation
- •Undergoing isolated robotic mitral annuloplasty at Mayo Clinic Rochester
- •Patients must have the ability to consent or have an appropriate representative available to do so.
Exclusion Criteria
- •Prior valve intervention,
- •Concomitant valve surgery at the time of mitral annuloplasty (e.g. tricuspid annuloplasty, aortic valve replacement).
- •Concomitant \>= moderate regurgitation or stenosis in any other valve by preoperative echocardiography
- •History of prior myocardial infarction
- •History of cardiomyopathy unrelated to mitral regurgitation (e.g. dilated, hypertrophic, infiltrative)
- •Pregnancy. Women of childbearing potential will be verbally screened by clinical staff during as part of routine pre-MRI evaluation. If a subject is unsure whether they could be pregnant, a negative pregnancy test will be performed prior to scanning.
- •Implantable devices that would be a contraindication to MRI
- •Severe allergy to gadolinium MRI contrast
Arms & Interventions
Chronic severe primary mitral regurgitation
Adults with chronic severe primary mitral regurgitation undergoing robotic mitral annuloplasty at Mayo Clinic Rochester
Intervention: Cardiac MRI
Outcomes
Primary Outcomes
Recruitment Rate
Time Frame: 2 years
Number of subjects consented to participate in study
Dropout Rate
Time Frame: 2 years
Number of subjects to withdraw from study
Systolic Dysfunction
Time Frame: 2 years
Number of subjects to experience postoperative systolic dysfunction, defined as Left ventricular ejection fraction (LVEF) \< 50%