The effect of vitamin C supplementation on inflammation levels, cognitive symptoms and depression in type 2 diabetes patients

Phase 3

Recruiting

Conditions: Type 2 diabetes.
Diabetes mellitus due to underlying condition

Registration Number: IRCT20230702058641N1

Lead Sponsor: Shahre-kord University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 19

Inclusion Criteria

30-65 years old
Not using corticosteroids and anticoagulants in the last month
Not using oral contraceptives in the last month
Not smoking
People who have not received vitamin C supplements at least 3 months before the test
People who are not professional athletes
People are placed in two equal groups in terms of receiving metformin/insulin
Patients should not take melatonin, aspirin, D3, or omega-3 during the study

Exclusion Criteria

Non-cooperation of patients to participate in the study
The presence of congenital cognitive and anxiety diseases
Incomplete completion of the questionnaire
People taking combined oral blood sugar-lowering drugs such as Synoripa tablets ...
people taking drugs related to severe depression (bipolar).

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean scores of cognitive symptoms. Timepoint: At the beginning of the study and after three months after starting to use ascorbic acid or placebo. Method of measurement: Addenbrooke's Cognitive Examination.;Depression change score. Timepoint: At the beginning of the study and after three months after starting to use ascorbic acid or placebo. Method of measurement: Depression- Anxiety- Stress Scale.

Secondary Outcome Measures

Name	Time	Method
evel of Interleukin 6 in the serum. Timepoint: At the beginning of the study and after three months after starting to use ascorbic acid or placebo. Method of measurement: Real-time PCR technique.