Is Tuberculin Skin Testing Effective in Screening for Latent Tuberculosis in Patients With HIV?

Completed

• Conditions: Latent Tuberculosis; HIV Infections
• Interventions: Other: T-Spot.TB test

• Registration Number: NCT00763295
• Lead Sponsor: Northwell Health

Brief Summary

HIV infection highly increases the risk of progression of latent tuberculosis (TB) to active disease that therapy is recommended for all PPD-positive, HIV-infected patients, regardless of age. Sensitivity of the PPD testing is, however, dependent on a normal T cell function.

Therefore, an accurate and reliable method for detection of latent tuberculosis in patients with HIV is urgently needed.

This prospective study will examine the utility of interferon-gamma (IFN-γ) based assay, T-SPOT.TB,for detection of TB in HIV-infected individuals.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-05
• Study First Submitted: 2008-09-28
• Study First Submitted QC: 2008-09-28
• Study First Posted: 2008-09-30
• Primary Completion: 2010-01
• Study Completion: 2010-01
• Status Verified: 2012-10
• Last Update Submitted: 2012-10-25
• Last Update Posted: 2012-10-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 53

Inclusion Criteria

Not provided

Exclusion Criteria

• Patients who are on INH treatment
• Patients who have a positive PPD test within 1 year of study enrollment
• Individuals with blistering or ulcerating skin disorder
• Pregnant women
• Patients who were given blood transfusion within 6 weeks prior to enrollment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
HIV infection	T-Spot.TB test	-

Trial Locations

Locations (1)

Staten Island University Hospital; 🇺🇸 Staten Island, New York, United States