Acute Food INtake Effect of Hemp Protein (A FINEH Protein) Trial - Part 2 - Are Acute Effects of Hemp Protein on Blood Glucose and Appetite Insulin-dependent?
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Manitoba
- Enrollment
- 15
- Locations
- 2
- Primary Endpoint
- Plasma Glucose and Insulin Concentrations
Study Overview
Brief Summary
The objectives of this trial are to investigate whether the effects of hemp protein on glycemic and appetite control are insulin-dependent by measuring 1) blood glucose, insulin and appetite for one hour following consumption, 2) blood glucose, insulin and appetite following a fixed energy meal to determine the "second meal effect" of hemp protein versus soybean protein and a non-protein control.
Detailed Description
The objectives of this trial are to investigate whether the effects of hemp protein on glycemic and appetite control are insulin-dependent by measuring 1) blood glucose, insulin and appetite for one hour following consumption, 2) blood glucose, insulin and appetite following a fixed energy meal to determine the "second meal effect" of hemp protein versus soybean protein and a non-protein control. The objectives of this trial are to investigate whether the effects of hemp protein on glycemic and appetite control are insulin-dependent by measuring 1) blood glucose, insulin and appetite for one hour following consumption, 2) blood glucose, insulin and appetite following a fixed energy meal to determine the "second meal effect" of hemp protein versus soybean protein and a non-protein control.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Normoglycemic (<5.6 mmol/L)
- •Body mass index (BMI) of 18.5-29.9 kg/m2.
Exclusion Criteria
- •Restrained eaters
- •Regularly skip breakfast
- •Those on medications that may influence study outcomes or have experienced any gastrointestinal related health conditions/surgeries over the past year.
Outcomes
Primary Outcomes
Plasma Glucose and Insulin Concentrations
Time Frame: 0-200 minutes
Measured in blood using intravenous catheter at 12 time points, used to calculate area under curve (AUC). Glucose will be determined by automated methods using Abbot Spectrum CCX Analyzer, and Insulin will be measured by commercially available RIA kits. (Composite measure)
Food Intake
Time Frame: 0-200 minutes
Measured by fixed energy meal.
Blood Pressure
Time Frame: 0-200 minutes
Measured by automated bood pressure cuff.
Appetite
Time Frame: 0-200 minutes
Measured by VAS Questionnaire.
Secondary Outcomes
- Palatability of Treatments and Meal(5-80 minutes)
- Physical Comfort(0-200 minutes)
- Energy/Fatigue(0-200 minutes)