Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients
Recruiting
- Conditions
- Surgical Site Infection
- Interventions
- Other: Surgical Site Infection
- Registration Number
- NCT04773457
- Lead Sponsor
- Boston Children's Hospital
- Brief Summary
Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 220
Inclusion Criteria
- scheduled for an elective open gastrointestinal surgical procedure or spine fusion surgery
Exclusion Criteria
- On chronic immunosuppressive drugs such as chronic corticosteroid use
- preexisting immunodeficiency diseases
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Spine Surgery Surgical Site Infection Pediatric patients presenting for elective spine fusion surgery at Boston Children's Hospital Abdominal Surgery Surgical Site Infection Pediatric patients presenting for elective abdominal surgery at Boston Children's Hospital
- Primary Outcome Measures
Name Time Method Neutrophil populations up to 3 days compare neutrophil population between patients with SSI and without SSI by delineating transcriptomic profiles
Neutrophil functional impairment up to 3 days illustrate neutrophil subpopulation associated with neutrophil functional impairment and SSIs by probing phagocytosis and reactive oxygen species formation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Boston Children's Hopsital
🇺🇸Boston, Massachusetts, United States