Effects of Parmigiano Reggiano on Muscle and Inflammatory Response to Eccentric Resistance Training in Older Adults

Not Applicable

• Conditions: Inflammation; Aging; Atrophy, Muscular; Cholesterol Deposition
• Interventions: Dietary Supplement: Whey Protein; Dietary Supplement: Parmigiano Reggiano

• Registration Number: NCT04861857
• Lead Sponsor: University of Padova

Brief Summary

Aging is associated with the loss of muscle mass and function (sarcopenia) and reduced tissue regenerative capacity.

Eccentric exercise (ECC) is a model of RET that can be used with the elderly, due to the ability of the muscle to combine high muscle strength production with low energy cost. ECC contractions are significantly more damaging to the muscles and produce greater muscle strength, for these reasons there is a greater risk of inducing muscle damage before the muscle is able to adapt.

Parmigiano Reggiano (PR) has some peculiar bromatological characteristics. The proteins contained in it, and in particular the potentially bioactive peptide sequences, can rapidly provide the amino acids necessary to promote muscle growth and repair during exercise. Furthermore, PR can be an important source of fatty acids, of which a significant amount of short-chain fatty acids (SCFA) which are known to have important clinical effects on body composition and metabolic health and can have a systemic anti-inflammatory effect.

Therefore, the central hypothesize is that PR consumed while being engaged in a RET can provide more energy substrates and improve muscle recovery, redcue inflammatory markers and improve lipid metabolism. To date, no studies have studied its function on recovery from exercise nor in the elderly.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-01
• Study First Submitted: 2021-04-23
• Study First Submitted QC: 2021-04-23
• Study First Posted: 2021-04-27
• Last Update Submitted: 2021-04-29
• Study Start: 2021-05-01
• Last Update Posted: 2021-05-05
• Primary Completion: 2022-03-31
• Study Completion: 2022-08-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• age >60 years
• BMI >18 and <30 kg/m2
• stable body weight in the past 3 months
• valid medical certifacate for practice of physical activity

Exclusion Criteria

• diabetes or pre-diabetes as for ADA guidelines
• chronic diseases (cardiovascular, liver, respiratory, cancer, etc)
• acute inflammatory status
• regular practice of intense physical activity (>2 sessions/week)
• treatment with steroids in the past 3 months
• regular use of >50g/die of Parmigiano Reggiano

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Whey Protein	Whey Protein	participants will consume 20 g/die of the dietary supplement and undergo to eccentric exercise training 3 times/week
Parmigiano Reggiano	Parmigiano Reggiano	participants will consume 50 g/die of the dietary supplement and undergo to eccentric exercise training 3 times/week

Primary Outcome Measures

Name	Time	Method
Leg lean Mass	Change from baseline to up to 12 weeks	kg of lean mass measured via DEXA

Secondary Outcome Measures

Name	Time	Method
inflammatory marker: IL-6	Change from baseline to up to 12 weeks	levels of plasma IL-6 (mg/dL)
cholesterol	Change from baseline to up to 12 weeks	levels of plasma cholesterol (mg/dL)

Trial Locations

Locations (1)

Nutrition and Exercise Lab, DSB, University of Padova; 🇮🇹 Padova, Italy