Effects of Parmigiano Reggiano on Skeletal Muscle Damage in Older Adults
- Conditions
- Inflammatory ResponseMuscle SorenessOld Age; Atrophy
- Interventions
- Dietary Supplement: Parmigiano ReggianoDietary Supplement: Whey Protein
- Registration Number
- NCT04872374
- Lead Sponsor
- University of Padova
- Brief Summary
Aging is associated with the loss of muscle mass and function (sarcopenia) and reduced tissue regenerative capacity.
Eccentric exercise (ECC) is a model of RET that can be used with the elderly, due to the ability of the muscle to combine high muscle strength production with low energy cost. ECC contractions are significantly more damaging to the muscles and produce greater muscle strength, for these reasons there is a greater risk of inducing muscle damage before the muscle is able to adapt.
Parmigiano Reggiano (PR) has some peculiar bromatological characteristics. The proteins contained in it, and in particular the potentially bioactive peptide sequences, can rapidly provide the amino acids necessary to promote muscle growth and repair during exercise. Furthermore, PR can be an important source of fatty acids, of which a significant amount of short-chain fatty acids (SCFA) which are known to have important clinical effects on body composition and metabolic health and can have a systemic anti-inflammatory effect.
Therefore, the central hypothes is that PR consumed during RET can provide more energy substrates and improve muscle recovery. To date, no studies have studied its function on recovery from exercise nor in the elderly.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- age >60 years old or >18 and < 30 years old
- BMI >18 and <30 kg/m2
- stable body weight in the past 3 months
- valid medical certifacate for practice of physical activity
- diabetes or pre-diabetes as for ADA guidelines
- chronic diseases (cardiovascular, liver, respiratory, cancer, etc)
- acute inflammatory status
- regular practice of intense physical activity (>2 sessions/week)
- treatment with steroids in the past 3 months
- regular use of >50g/die of Parmigiano Reggiano
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Older adults Parmigiano Reggiano participants will perform an eccentric exercise bout after 10 days of dietary supplementation Young adults Whey Protein participants will perform an eccentric exercise bout after 10 days of dietary supplementation Young adults Parmigiano Reggiano participants will perform an eccentric exercise bout after 10 days of dietary supplementation Older adults Whey Protein participants will perform an eccentric exercise bout after 10 days of dietary supplementation
- Primary Outcome Measures
Name Time Method maximum volountary contraction (MVC) Change from baseline to up to 5 days maximal muscle volountary contraction mesured in Newton
- Secondary Outcome Measures
Name Time Method Creatin Kinase Change from baseline to up to 5 days plasmatic levels of Creatin Kinase (mmol/dL) as a markers of muscle damage
reactive Proteinc C Change from baseline to up to 5 days plasmatic levels of reactive Proteinc C (mg/dL) as a markers of muscle damage
IL-6 Change from baseline to up to 5 days plasmatic levels of IL-6 (mg/dL) as a markers of muscle damage
delayed onset muscle soreness (DOMS) Change from baseline to up to 5 days level of delayed onset muscle soreness (DOMS) masured via Visual Analogue Scale (VAS) scale where 0 is the minimal value (no pain) and 10 is the maximum value (maximum pain).
Trial Locations
- Locations (1)
Nutrition and Exercise Lab, DSB, University of Padova
🇮🇹Padova, Italy