Effect of Vitamin D Injection on Hypertrophic Scars and Keloids
- Registration Number
- NCT06301178
- Lead Sponsor
- Mostafa Bahaa
- Brief Summary
Scars and keloids cause patients severe morbidity and psychological distress. Hypertrophic scars rise above the skin but stay within the scar boundaries, while keloids expand.
The development of keloids and hypertrophic scars is a consequence of insufficient wound healing. These lesions are distinguished by excessive ECM deposition. Excessive ECM deposition is caused by increased inflammatory and proliferative processes and decreased remodeling activities. These scarring lesions are also linked to genetic and systemic causes
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 35
- Age from 12 years to 50 years. Patients with hypertrophic scars and keloids
Age below 12 years and above 50 years. Patients received other treatment modalities for hypertrophic scars and keloids.
Systemic and other skin diseases. Patients were already receiving supplemental vitamin D.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description vitamin D deficiency Cholecalciferol patients with vitamin D deficiency or insufficiency (\<12 ng/ml and 12-19 ng/ml, respectively) received systemic and intralesional vitamin D injections vitamin D sufficiency Cholecalciferol Patients with vitamin D sufficiency (20 and greater ng/mL) of vitamin D received only intralesional injections of vitamin D on hypertrophic scars and keloids.
- Primary Outcome Measures
Name Time Method Clinical scoring by Vancouver Scale Score 3 months Four characteristics of the scar are assessed. These are: vascularity, height, pliability, and pigmentation. Each characteristic is given a score, which are added together to give an overall score between 0 and 13
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
faculty of medicine-Fayoum university
🇪🇬Fayoum, Egypt