Metabolic Response to 3-day Fast Versus Carbohydrate-free Diet in Type 2 Diabetes
Not Applicable
Completed
- Conditions
- Type 2 Diabetes
- Interventions
- Other: 3 day fastOther: 3 day CHO-free diet
- Registration Number
- NCT01469104
- Lead Sponsor
- Minneapolis Veterans Affairs Medical Center
- Brief Summary
The investigators hypothesis is that a carbohydrate-free diet, ingested for 3 days, results in a change in blood glucose that is similar to the change observed after 3 days of fasting.
- Detailed Description
In addition to plasma glucose concentrations, other hormones and metabolites known to be affected by fasting will be measured. These include insulin and glucagon, which are hormones that have an important role in regulating fuel use in the body.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 7
Inclusion Criteria
- Type 2 diabetes
- C-peptide > 1.5 ng/ml
Exclusion Criteria
- Body mass index > 40
- hematological abnormalities
- liver disease
- kidney disease
- congestive heart failure
- life threatening malignancies
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 3 day fast 3 day fast After receiving a standard diet on day 1, subject will fast on days 2, 3, and 4. Water and calorie-fee beverages will be allowed during this 72 hour period. CHO-free diet 3 day CHO-free diet After receiving a standard diet on day 1, a carbohydrate-free diet will be provided on days 2, 3, and 4.
- Primary Outcome Measures
Name Time Method Change in plasma glucose concentration 24 hour profile:before and after meals, or traditional meal times
- Secondary Outcome Measures
Name Time Method Change in serum insulin concentrations 24 hour profiles: before and after meals or traditional meal times
Trial Locations
- Locations (1)
Minneapolis VA Health Care System
🇺🇸Minneapolis, Minnesota, United States