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Metabolic Response to 3-day Fast Versus Carbohydrate-free Diet in Type 2 Diabetes

Not Applicable
Completed
Conditions
Type 2 Diabetes
Registration Number
NCT01469104
Lead Sponsor
Minneapolis Veterans Affairs Medical Center
Brief Summary

The investigators hypothesis is that a carbohydrate-free diet, ingested for 3 days, results in a change in blood glucose that is similar to the change observed after 3 days of fasting.

Detailed Description

In addition to plasma glucose concentrations, other hormones and metabolites known to be affected by fasting will be measured. These include insulin and glucagon, which are hormones that have an important role in regulating fuel use in the body.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
7
Inclusion Criteria
  • Type 2 diabetes
  • C-peptide > 1.5 ng/ml
Exclusion Criteria
  • Body mass index > 40
  • hematological abnormalities
  • liver disease
  • kidney disease
  • congestive heart failure
  • life threatening malignancies

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Primary Outcome Measures
NameTimeMethod
Change in plasma glucose concentration24 hour profile:before and after meals, or traditional meal times
Secondary Outcome Measures
NameTimeMethod
Change in serum insulin concentrations24 hour profiles: before and after meals or traditional meal times

Trial Locations

Locations (1)

Minneapolis VA Health Care System

🇺🇸

Minneapolis, Minnesota, United States

Minneapolis VA Health Care System
🇺🇸Minneapolis, Minnesota, United States

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