High-Risk Factors in Patients With Colorectal Polyps a Prospective Case-Control Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Colorectal Polyp
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
- Enrollment
- 2800
- Locations
- 1
- Primary Endpoint
- Demographic and clinicopathological characteristics of participants with polyps
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This prospective case-control study aimed to analyze and summarize the high-risk factors and susceptible genes of patients with colorectal polyps. According to these high-risk factors, the investigators developed and validated a prediction model for colorectal polyps to identify high-risk individuals, in order to provide clinical basis for the etiology research and the establishment of effective preventive measures.
Detailed Description
A large cohort of eligible participants were included in the analysis, and classified into derivation and validation cohorts at a ratio of 7:3. Demographic and clinicopathological characteristics of participants were utilized to develop a prediction model for colorectal polyps. In the derivation cohort, the LASSO regression method was applied to filter variables and select the most useful high-risk factors. Multivariate logistic regression analysis was used to identify potential predictors and then a prediction model was established. The predictive performance of the model was evaluated with respect to its discrimination, calibration and clinical usefulness.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Subject aged ≥18 and ≤80 years old. Subject with complete data on demography and clinicopathology.
Exclusion Criteria
- •Subject with inflammatory bowel disease, enterophthisis, familial adenomatous polyposis, P-J syndrome and intestinal lymphoma.
- •A history of severe systemic diseases: liver cirrhosis, metabolic syndrome, chronic kidney disease, malignancy.
- •Subject taking blood lipid-lowering drugs, hormone or immunosuppressive agents. Unwillingness to cooperate with questionnaire survey. Lack of complete clinical data for analysis.
Outcomes
Primary Outcomes
Demographic and clinicopathological characteristics of participants with polyps
Time Frame: 1 year
demographic and clinicopathological characteristics
Secondary Outcomes
- Independent high-risk factors of participants with polyps(1 year)