Hyperinflation in COPD exacerbations

Completed

Conditions: Chronic Obstructive Pulmonary Disease
COPD
lung emfysema and chronic bronchitis
10024970

Registration Number: NL-OMON40607

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

Male or Female, 40 years or older
Doctor*s diagnosis of COPD.
Experiencing an exacerbation of COPD requiring hospitalization at the moment of inclusion. An exacerbation is defined as a worsening of respiratory symptoms from the stable state and beyond normal day-to-day variations, which requires additional treatment.
Patients must be able to understand and complete protocol requirements, Instructions and questionnaires in Dutch
Written Informed consent

Exclusion Criteria

If any of these criteria are absent at admission, but occur during the course of the study, patients will be followed up within the protocol as much as possible.
Pneumonia confirmed with X ray
COPD exacerbation requiring (non) invasive ventilation or admittance to an intensive care unit
Patient who received any investigational new drug within the last 4 weeks prior to admission or twice the duration of the biological half-life of any investigational new drug (whichever is longer).
Unstable angina pectoris or other clinically important cardiac co-morbidity requiring admission on a cardiology ward

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Temporal relation between changes in hyperinflation (as measured by inspiratory<br /><br>capacity) during resolution of the exacerbation, and changes in HR-QoL and<br /><br>dyspnoea. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Other HR-QoL and dyspnea patient report outcomes (PRO)'s<br /><br>Lung function parameters: dynamic hyperinflation, TLC, diffusion, FEV1, FVC,<br /><br>IOS, single breath nitrogen washout.<br /><br>Enose for measurement of exhaled organic compounds<br /><br>Inflammation parameters measured by blood sample and nasopharyngeal swab<br /><br>Infection as assessed by routine lab and cultures<br /><br>Length of stay in the hospital</p><br>