Evaluating the usefulness of CT-scans in the diagnosis and management of chronic obstructive pulmonary disease (COPD) patients with respiratory symptoms.
Not Applicable
- Conditions
- Diagnosis and management of COPD patients with exacerbation of respiratory symptomsRespiratoryChronic obstructive pulmonary disease
- Registration Number
- ISRCTN39235677
- Lead Sponsor
- niversity Hospital of Basel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 310
Inclusion Criteria
1. Diagnosed or suspected COPD
2. Able to give informed consent as documented by signature
3. Age =40 years
4. Smoking history =20 PY
5. Suspicion of exacerbation of respiratory symptoms
Exclusion Criteria
1. Pregnant or lactating women
2. Inability or contraindications to undergo a CT-scan eg. pregnancy
3. Clinically significant concomitant diseases such as organ transplantation
4. Acute coronary syndrome – emergency angiography
5. Inability to follow the procedures of the study, e.g. due to language problems, dementia, etc.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Length of hospital stay measured in days reviewing the medical records<br> 2. Diagnosis and therapy recorded before radiographic finding, after radiographic finding and at discharge by the treating physician<br>
- Secondary Outcome Measures
Name Time Method <br> 1. Symptoms measured using the EXACT score questionnaire at baseline, 7, 14, 21 and 28 days<br> 2. COPD assessment test (CAT score questionnaire) at baseline and 30 (+7) days<br> 3. Modified Medical Research Council (MMRC) dyspnea scale at 28 days<br> 4. Circulating biomarkers of COPD severity and outcome measured using blood sample at 28 days<br> 5. Mortality up to 30 (+7) days measured using patient records<br> 6. DECAF score for acute exacerbation measured through Dyspnoea (Questionnaire), Eosinopenia (blood), Consolidation (radiographic finding), Acidaemia (blood gas analysis) and atrial fibrillation (electrocardiogram) at baseline<br>