Synergistic Effects of Stress and Sugar Feeding on Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- 24-hour triglyceride area under the curve
研究概览
简要总结
The main objectives of this study are to test the hypotheses that: 1) consumption of beverages sweetened with sucrose will increase risk factors for cardiovascular disease to a greater extent than a naturally-sweetened fruit juice such as orange juice, and 2) chronic psychological stress may augment the adverse metabolic effects of sugar intake. The study intervention consists of 2-week's consumption of 25% of energy as sugar provided either as a sucrose-sweetened beverage or naturally-sweetened orange juice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Body mass index between 28-35
- •Self report of stable body weight during the past six months
- •High stress participants: Perceived Stress Scores (PSS) ≥ 24, and the presence of a predefined chronically stressful event as assessed by the Telephone screening questions. (IDS scores are not an inclusion criteria in this group, merely a rule-out for the low stress participants).
- •Low stress participants: PSS scores ≤ 8, Inventory for Depressive Symptom (IDS) scores ≤ 14, and the absence of any predefined chronically stressful events as assessed by the telephone screening questions.
排除标准
- •glucose intolerance
- •Evidence of liver disorder
- •Evidence of kidney disorder
- •Evidence of thyroid disorder
- •Systolic blood pressure consistently over 140mmHg or diastolic blood pressure over 90mmHg
- •Triglycerides > 200mg/dl
- •LDL-C > 130mg/dl
- •Hemoglobin < 8.5 g/dl
- •pregnant or lactating women
- •Current, prior (within 12 months), or anticipated use of any hypolipidemic or anti-diabetic agents
- •Use of Selective Serotonin Reuptake Inhibitors and anti-hypertensive medications
- •Any other condition that, in the opinion of the investigators, would put subject at risk
- •Strenuous exerciser
- •surgery for weight loss
- •Diet exclusions: food allergies, special dietary restrictions, habitual ingest of >2 alcoholic beverages/day
研究组 & 干预措施
orange juice
no sugar
干预措施: orange juice (Other)
orange juice
no sugar
干预措施: sucrose (Other)
sugar beverage
no sugar
干预措施: orange juice (Other)
sugar beverage
no sugar
干预措施: sucrose (Other)
结局指标
主要结局
24-hour triglyceride area under the curve
时间窗: Baseline and 2-week intervention
28 serial blood samples are collected over a 24 hour period.
次要结局
- Markers of immune cell aging(Baseline and 2-week intervention)