Plasticity of Neonatal Neuronal Networks Temporal Theta Activity, the First Endogenous

Completed

• Conditions: Premature Birth
• Interventions: Other: ElectroEncephaloGraphy

• Registration Number: NCT03677908
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms. The sources of TTA-SW were localized by high-density EEG using different tissues conductivities, head models and mathematical models.

Detailed Description

Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms.

Study Timeline

• Study Start: 2016-07-01
• Primary Completion: 2017-01-01
• Study Completion: 2017-01-01
• Status Verified: 2018-09
• Study First Submitted: 2018-09-14
• Study First Submitted QC: 2018-09-18
• Last Update Submitted: 2018-09-18
• Study First Posted: 2018-09-19
• Last Update Posted: 2018-09-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• healthy premature infants
• Gestational Ages of 26 and 32 wGA

Exclusion Criteria

• unhealthy premature infants

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
15 low	ElectroEncephaloGraphy	Low-Density ElectroEncephaloGraphy analysis of other 15 healthy premature infants
13 high	ElectroEncephaloGraphy	High-Density ElectroEncephaloGraphy analysis of 13 healthy premature infants

Primary Outcome Measures

Name	Time	Method
specific temporal TTA-SW	2 months	The objective of this study is to evaluate the spatial organization of the specific Temporal theta slow-wave activity (TTA-SW) with the Low-Density Electroencephalography (LD-EEG) at an early stage of development in humans to demonstrate that TTA-SW were independent of auditory stimuli.