Genetic Risk Factors for Severe Asthma
- Conditions
- Asthma
- Registration Number
- NCT00090740
- Brief Summary
The purpose of this study is to determine whether a specific genetic factor influences the severity of asthma symptoms.
- Detailed Description
Asthma is one of the most common chronic diseases in the United States. It is well known that asthma susceptibility is inherited; however, it is unknown if asthma severity is heritable. Studies suggest that levels of interleukin-16 (IL-16) may influence asthma severity. This study will examine the role of differences in the control region of the IL-16 gene in a racially diverse group of asthmatics and nonasthmatics and will determine if the IL-16 gene control region is related to asthma severity.
Participants in this study will undergo lung function and blood tests; they will also complete a questionnaire about their respiratory health. Asthmatic participants will complete a severity-of-asthma questionnaire.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 600
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Examination of the relationship between the IL-16 promoter genotype and the presence of the asthma phenotype Throughout study Examination of the serum IL-16 concentration and the serum IL-16:IL-9, IL-16:IL-13, and IL-16: TNF-alpha ratios as possible intermediate phenotypes lining the IL-16 promoter genotype to asthma severity Throughout study Examination of the relationship between the IL-16 promoter genotype and asthma severity Throughout study
- Secondary Outcome Measures
Name Time Method Storage of DNA from all 600 participants for future study into the determinants of asthma severity Throughout study
Trial Locations
- Locations (1)
Boston University School of Medicine
🇺🇸Boston, Massachusetts, United States