LCD Solution Versus Calcipotriol Cream in the Treatment of Moderate Plaque Psoriasis

Not Applicable

Completed

• Conditions: Chronic Plaque Psoriasis
• Interventions: Drug: LCD; Drug: calcipotriol

• Registration Number: NCT00705900
• Lead Sponsor: NeoStrata Company, Inc.

Brief Summary

The purpose of this study is to compare the safety and effectiveness of a new topical LCD solution and a commercially available calcipotriol (Vitamin D) cream in reducing the symptoms of plaque psoriasis and improving the quality of life in adults.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Study First Submitted: 2008-06-25
• Study First Submitted QC: 2008-06-26
• Study First Posted: 2008-06-27
• Status Verified: 2008-11
• Primary Completion: 2008-11
• Study Completion: 2008-11
• Last Update Submitted: 2008-11-17
• Last Update Posted: 2008-11-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 18 years of age or older
• able and willing to provide written informed consent
• diagnosed with chronic plaque psoriasis
• 3% to 15% body surface area involved
• in good general health

Exclusion Criteria

• other current treatments for psoriasis
• renal or liver dysfunction
• pregnant or nursing

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	LCD	LCD Solution: 2 applications / day
2	calcipotriol	Calcipotriol cream: 2 applications / day

Primary Outcome Measures

Name	Time	Method
Difference in percent reduction in Psoriasis Area and Severity Index (PASI) Scores between treatment arms	12 weeks of treatment

Secondary Outcome Measures

Name	Time	Method
Changes in PLASI, PEASI, Physician Global Assessment (PGA), Pruritus, and Dermatology Life Quality Index (DLQI) Scores between treatment arms	Week 12 and Week 18

Trial Locations

Locations (1)

Mass General Hospital: Clinical Unit for Research Trials in Skin; 🇺🇸 Boston, Massachusetts, United States