A study of exercise versus rest in myasthenia gravis
Phase 3
Completed
- Conditions
- Health Condition 1: G700- Myasthenia gravis
- Registration Number
- CTRI/2019/11/021869
- Lead Sponsor
- Prinicipal Investigator
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
1. MG patients attending the neurology Outdoor or indoor services of SGPGIMS.
2. MGFA score of stage II to III.
3. Able to undergo 6minute walk test
Exclusion Criteria
1. Enrolled in another trial. 2. Contraindications to exercise like coronary artery disease and stroke and pulmonary disease, osteoarthritis, pregnancy or medical condition reducing survival to less than 2 years.
3. Hospitalization in past 8 weeks. 4. MGFA score of stage I, IV or V. 5. MGQOL score > 45.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MGQOL-15 scoreTimepoint: 1,2 and 3 months <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1. Increase in the dose of AchEIs drugs or additional immunosuppression or use of PE,IVIG. <br/ ><br>2. Myasthenic muscle score: at 1,2 and 3 month. <br/ ><br>3. Change in MGADL. <br/ ><br>4. Grip strength. <br/ ><br>5. Six min walk test. <br/ ><br>6. RNS in Trapezius <br/ ><br>7. Micro RNA: -150 -5P and micro RNA- 21- 5P. <br/ ><br>8. Endorphin and its receptors.Timepoint: 1,2 and 3 months