Systemic Effects of A Continuous Blood Flow Restricted Aerobic Exercise Session in COPD Patients: A Randomised Controlled Trial.
- Conditions
- COPD
- Interventions
- Procedure: aerobic exercise with blood flow restriction
- Registration Number
- NCT04526184
- Lead Sponsor
- Medipol University
- Brief Summary
Patients with COPD that a pulmonologist classifies between Stage 1-2 in accordance with the GOLD criteria and age and gender-matched healthy individuals will be included in the study.
In both groups (n = COPD: 17, Healthy: 17), aerobic exercise (AE) in the target heart rate range of 50% intensity, performed by cycling accompanied by blood flow restriction, will be applied.
- Detailed Description
Target heart rate will be calculated from the formula "(Maximal heart rate-resting heart rate) x% desired intensity ratio + resting heart rate".
The target occlusion amount in the lower extremity will be calculated by calculating 45% of the complete occlusion rates reported by Michael et al. The proximal border of the thigh cuffs will be tied in line with the gluteal lines on both sides.
Exercise tolerance and dyspnea condition; Measurement properties in COPD will be evaluated using a well-defined modified Borg scale (MBS). Individuals will use any bronchodilator that their doctor sees fit before trying.
The target aerobic exercise intensity will be reached in the last minute of the first five-minute warm-up period by maintaining a 4-6 feeling of dyspnea in the MBS, by increasing pedal resistance and speed. In case of extreme shortness of breath, exercise intensity will be reduced to resting heart rate.
In the event of oxygen desaturation (85%) during the intervention, the intervention will be terminated.
Aerobic exercise training protocol; It was planned as 50 rpm speed and warming up at the lowest pedal resistance during the first 4 minutes, reaching the target exercise intensity range in the next 1 minute, aerobic training at the target heart rate range and appropriate MBS value for the next 20 minutes, cooling down in the last 5 minutes. The duration will be reduced in case of excessive shortness of breath, fatigue and muscle pain due to increased exercise volume. The distance, calories, and maximum speed values measured during the study will be recorded.
Before and immediately after the study, all participants had muscle damage (creatine kinase), anti-inflammatory response (CRP, neutrophil), oxidative stress response (uric acid, LDH), oxygen saturation, heart rate, systolic and diastolic pressure will be examined.
Institution of the Study: Karabuk University Research Hospital Chest Diseases Clinic Center / Karabuk. The study would be conducted in the presence of a chest diseases specialist.
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- Male
- Target Recruitment
- 46
- No drug change for at least 30 days for the COPD group
- Not participating in a structured activity program for at least six months
- Have the ability to cooperate
- Presence of any pathology that limits physical activity performance
- Presence of severe or unstable heart disease
- Presence of peripheral artery disease
- Being in an exacerbation period of the disease
- Presence of another active disease (rheumatic, oncological, traumatic etc.)
- Any neurological or orthopedic disease that prevents exercise
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description patient group aerobic exercise with blood flow restriction 25 individuals will be selected randomly from 103 patients with COPD from hospital records. healthy group aerobic exercise with blood flow restriction 25 healthy individuals between the ages of 40-70 will be contacted by phone and included in the initiative.
- Primary Outcome Measures
Name Time Method C reactive protein, neutrophil 30 minutes inflammatory marker
modified borg scale up to 18 weeks. dyspnoea measurement, Minimum 1, maximum 7 points are obtained. 5 indicates the best respiratory condition, 10 the worst respiratory condition.
oxidative stress markers up to 18 weeks uric acid, lactate dehydrogenase
creatine kinase 30 minutes rhabdomyolysis marker
heart rate 30 minutes determination of aerobic exercise dose
oxygen saturation 30 minutes blood oxygen saturation
systolic and diastolic pressure up to 18 weeks to mean arterial pressure calculation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Karabük Üniversitesi Araştırma Hastanesi Göğüs Hastalıkları Kliniği
🇹🇷Karabük, Turkey