Progesterone-Primed Ovarian Stimulation Might be a Safe and Effective Alternative to GnRH-antagonist Protocol for Controlled-Ovarian Stimulation of Infertile PCOS Women
Overview
- Phase
- Not Applicable
- Intervention
- Injection of Cetrorelix
- Conditions
- PCOS
- Sponsor
- Zagazig University
- Enrollment
- 238
- Locations
- 1
- Primary Endpoint
- Success rate of PPOS in relation to Premature LH surge suppression
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The study evaluated the safety and efficacy of the progesterone-primed ovarian stimulation (PPOS) coupled with gonadotropin (FSH) for infertile women with polycystic ovary syndrome (PCOS) who were assigned for ICSI and frozen blastocyst transfer.
200 infertile women were divided randomly into Group C, which received Cetrorelix injection (0.25 mg daily) on day-6, and Group S, which received oral dydrogesterone (20 mg/day) on day-2 of the menstrual cycle till the trigger day. All patients received an FSH injection of 225 IU daily from day-2 till triggering day. ICSI was performed and day-5 blastocysts underwent vitrification ultra-rapid cryopreservation till being transferred. Outcomes included the ability of PPOS to suppress the premature luteinizing hormone (LH) surge and prevent the development of ovarian hyperstimulation syndrome (OHSS), the incidence of profound LH suppression, the number of retrieved M2 oocyte and fertilization, chemical and clinical pregnancy rates, and the miscarriage rate.
Investigators
Walid Mohamed Elnagar
Assistant professor of gynecology
Zagazig University
Eligibility Criteria
Inclusion Criteria
- •Infertile PCOS women;
- •aged 20-35 years;
- •had BMI \<35 kg/m2.
Exclusion Criteria
- •Women who were younger than 20 or older than 35 years,
- •obese of grade II or III,
- •had poor OR, other causes of infertility,
- •had previous attempts of IVF, had a history of repeated pregnancy loss.
Arms & Interventions
Group C
Intervention: Injection of Cetrorelix
Group S
Intervention: Oral insertion of dydrogeserone
Outcomes
Primary Outcomes
Success rate of PPOS in relation to Premature LH surge suppression
Time Frame: 12 months
the success rate of PPOS as regards the suppression of premature LH surge and prevention of the development of OHSS.