Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Varicocele
- Sponsor
- Benha University
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- The Quality of Semen
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Varicocele is a major contributor in male infertility. The improvement of sperm parameters after varicocelectomy supports this contribution. The pathophysiological mechanisms of varicocele-induced male infertility are still under investigation. Cystatin C (Cys C) and endoglin are secreted glycoproteins that recently linked to several cellular changes common in varicocele like apoptosis and autophagy.
Detailed Description
Subinguinal varicocelectomy under general anesthesia and complete aseptic condition was done to infertile men with varicocele
Investigators
Essam Mohamed El-sayed Akl
Assistant Professor
Benha University
Eligibility Criteria
Inclusion Criteria
- •Infertile men
- •Varicocele
- •Poor sperm parameters
Exclusion Criteria
- •Men with systemic diseases
- •Infertile men due to other causes than varicocele
Outcomes
Primary Outcomes
The Quality of Semen
Time Frame: 6 months
According to WHO 2010 guidelines regarding semen analysis * Sperm concentration (to be more than 15 million sperm per milliliter). * Sperm motility (not less than 60% progressive motility). * Sperm morphology (not less than 6% normal morphology).