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Clinical Trials/NCT04411810
NCT04411810
Completed
N/A

SpotCheck: Comparison of Enhanced Telemedicine Versus In-person Evaluation for the Diagnosis of Skin Cancer

NYU Langone Health1 site in 1 country149 target enrollmentAugust 20, 2020
ConditionsSkin Cancer

Overview

Phase
N/A
Intervention
Not specified
Conditions
Skin Cancer
Sponsor
NYU Langone Health
Enrollment
149
Locations
1
Primary Endpoint
Accuracy of Skin Cancer Diagnosis: Telemedicine Without Nevisense
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

The overall goal of this research is to develop a platform that can increase patient access to expert skin cancer diagnostic services via telemedicine. This is especially important for medically underserved areas where melanoma outcomes are worse than in areas with greater access to in-person evaluations. If successful, the widespread availability of such services would be combined with public education efforts to encourage individuals with changing skin lesions to seek evaluation. With decreased travel times to high quality diagnostic services, such efforts may decrease the diagnosis of more advanced melanomas (with a concomitant increase in the diagnosis of earlier stage tumors), and potentially decrease melanoma mortality.

Detailed Description

This is a prospective pilot study of a store-and-forward telemedicine diagnostic assessment of participant-selected skin lesions concerning for skin cancer, controlled against an in-person dermatologist assessment (gold standard evaluation). The study will be a single arm design with each participant undergoing telemedicine data acquisition (i.e. clinical and dermoscopic imaging and Nevisense measurement), immediately followed by the in-person dermatologist assessment. The in-person dermatologist will be blinded to the Nevisense score at the time of the visit. Using the telemedicine data, the teledermatology team will render a biopsy/no-biopsy recommendation within 3 business days of the participant evaluation. They will be blinded to the results of the in-person dermatologist's diagnostic evaluation.

Registry
clinicaltrials.gov
Start Date
August 20, 2020
End Date
March 4, 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Be 18 years of age or older
  • Have 1-3 lesions for evaluation

Exclusion Criteria

  • Lesions of the hair-bearing scalp, in the mouth, on the lips, genitalia, nails, on/around the eyes, inside the ear

Outcomes

Primary Outcomes

Accuracy of Skin Cancer Diagnosis: Telemedicine Without Nevisense

Time Frame: End of the study (4 weeks)

To compare the accuracy of skin cancer diagnoses between in-person recommendation and the telemedicine (tele) recommendation, the number of "positive" evaluations (i.e. recommended for biopsy) that were truly skin cancer plus the number of "negative" evaluations (i.e. not recommended for biopsy) that were truly non-cancerous divided by the total number of skin lesions evaluated is calculated.

Accuracy of Skin Cancer Diagnosis: In-Person Assessment

Time Frame: End of the study (4 weeks)

To compare the accuracy of skin cancer diagnoses between in-person recommendation and the telemedicine (tele) recommendation, the number of "positive" evaluations (i.e. recommended for biopsy) that were truly skin cancer plus the number of "negative" evaluations (i.e. not recommended for biopsy) that were truly non-cancerous divided by the total number of skin lesions evaluated is calculated.

Accuracy of Skin Cancer Diagnosis: Telemedicine With Nevisense

Time Frame: End of the study (4 weeks)

To compare the accuracy of skin cancer diagnoses between in-person recommendation and the telemedicine (tele) recommendation, the number of "positive" evaluations (i.e. recommended for biopsy) that were truly skin cancer plus the number of "negative" evaluations (i.e. not recommended for biopsy) that were truly non-cancerous divided by the total number of skin lesions evaluated is calculated.

Secondary Outcomes

  • Specificity of In-Person Evaluation in Diagnosing Skin Cancer(End of the study (4 weeks))
  • False-Negative Rate of Telemedicine Evaluation: With Nevisense(End of the study (4 weeks))
  • Positive Predictive Value of Telemedicine Evaluation: Without Nevisense(End of the study (4 weeks))
  • Negative Predictive Value of In-Person Evaluation(End of the study (4 weeks))
  • False-Negative Rate of Telemedicine Evaluation: Without Nevisense(End of the study (4 weeks))
  • Positive Predictive Value of Telemedicine Evaluation: With Nevisense(End of the study (4 weeks))
  • Sensitivity of Telemedicine Evaluation in Diagnosing Skin Cancer: Without Nevisense(End of the study (4 weeks))
  • False-Negative Rate of In-Person Evaluation(End of the study (4 weeks))
  • Negative Predictive Value of Telemedicine Evaluation: Without Nevisense(End of the study (4 weeks))
  • Sensitivity of Telemedicine Evaluation in Diagnosing Skin Cancer: With Nevisense(End of the study (4 weeks))
  • False-Positive Rate of Telemedicine Evaluation: Without Nevisense(End of the study (4 weeks))
  • Sensitivity of In-Person Evaluation in Diagnosing Skin Cancer(End of the study (4 weeks))
  • Specificity of Telemedicine Evaluation in Diagnosing Skin Cancer: Without Nevisense(End of the study (4 weeks))
  • Specificity of Telemedicine Evaluation in Diagnosing Skin Cancer: With Nevisense(End of the study (4 weeks))
  • False-Positive Rate of Telemedicine Evaluation: With Nevisense(End of the study (4 weeks))
  • False-Positive Rate of In-Person Evaluation(End of the study (4 weeks))
  • Positive Predictive Value of In-Person Evaluation(End of the study (4 weeks))
  • Negative Predictive Value of Telemedicine Evaluation: With Nevisense(End of the study (4 weeks))

Study Sites (1)

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