Does midazolam plus haloperidol enhance morphine effect in opium dependent patients?
Phase 2
- Conditions
- Opium dependence syndrome.Mental and behavioral disorders due to use of opioids : dependence syndrome
- Registration Number
- IRCT2016041219971N2
- Lead Sponsor
- Vice chancellor for research, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 87
Inclusion Criteria
Adult (18 years and older) patients who were opium dependent and had been admitted to the emergency department because of pain.
Exclusion criteria: Age below 18 years; refuse to participation in the trial; inability to express or evaluate the pain (loss of consciousness, non-verbal patients due to articulation problems or mental decline); systolic blood pressure under 100 mm Hg; long QT interval in electrocardiogram and pregnancy.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain intensity. Timepoint: Pre-intervention and at 1,3,6 hours post intervention. Method of measurement: Numerical Rating Scale.;Morphine doses. Timepoint: 1,3 and 6 hours post-intervention. Method of measurement: Total doses of morphine (mg).
- Secondary Outcome Measures
Name Time Method Side effects. Timepoint: 1,3and 6 hours post intervention. Method of measurement: Observation and clinical examination.