Does propofol prevent morphine-induced nausea, vomiting and itching in women who have had a Caesarean section?
Not Applicable
Completed
- Conditions
- Morphine-induced postoperative nausea and vomiting in women who have had a Caesarean sectionInjury, Occupational Diseases, Poisoning
- Registration Number
- ISRCTN15475205
- Lead Sponsor
- niversity for Development Studies
- Brief Summary
2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/31521119 (added 16/09/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 345
Inclusion Criteria
Women undergoing elective Caesarean section
Exclusion Criteria
1. Women undergoing emergency Caesarean section
2. Women who have refused to give consent to the study
3. Any co-morbidity
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Episodes of postoperative nausea and vomiting (PONV) assessed using using a 3-point ordinal scale (0 = none, 1 = nausea, 2 = vomiting) recorded hourly for the first 4 h and then every 4 h for the next 24 h. The incidence of PONV was calculated and categorized as early (0-4 h) or delayed (5-24 h).<br> 2. Rescue antiemetic use up to 24 h after metoclopramide, propofol or saline administration<br>
- Secondary Outcome Measures
Name Time Method <br> 1. Episodes of pruritus assessed using a four-point categorical scale (0 = no pruritus, 1 = mild pruritus, 2 = moderate pruritus, 3 = severe pruritus) hourly for the first 4 hours and then 4 hourly for the next 48 hours after surgery<br> 2. Pain intensity assessed using a 100-mm visual analog scale VAS (Mc Cormack et al, 1988), where 0 mm = no pain, and 100 mm = intolerable pain, immediately after surgery<br> 3. Overall perioperative satisfaction evaluated during an interview, where 4 = excellent, 3 = good, 2 = satisfactory, 1 = poor, on the day of hospital discharge<br>