NCT02756637已完成不适用
Neutrophil-to-Lymphocyte Ratio in Bladder Cancer: A Secondary Biomarker Analysis of SWOG 8710
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 634
- 试验地点
- 1
- 主要终点
- Overall Survival
研究概览
简要总结
The purpose of this study is to perform a secondary analysis of SWOG 8710 to assess NLRs value as a biomarker. Specifically, the investigators test two hypotheses: 1) that baseline NLR is correlated with overall survival after curative treatment for BC and 2) that baseline NLR is correlated with the survival benefit of NAC. The study will look at the data from participants of the SWOG 8710 study.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •SWOG 8710 original trial inclusion criteria included:
- •Node-negative, muscle-invasive transitional cell carcinoma of the bladder, T2-T4aN0M0 per the AJCC 4th edition staging manual.
- •SWOG performance status of 0 or 1
- •Adequate organ function by lab criteria (WBC > 4,000 cells/mm3, platelets >150,000 cells/mm3, creatinine <1.5 md/dL (men) or <1.3 md/dL (women), baseline liver tests < 2 times normal limits)
- •Inclusion criteria for this secondary analysis are:
- •Eligible for original SWOG 8710 trial
- •Had complete blood count with differential prior to first treatment (radical cystectomy or NAC).
排除标准
- •SWOG 8710 original trial exclusion criteria included:
- •No age restrictions
- •Previous or concomitant malignancy other than bladder cancer or basal cell skin cancer
- •Prior pelvic radiation
- •Metastatic or incurable disease
- •Laboratory values exceeding those detailed in 3.1.c
- •Exclusion criteria for this secondary analysis are:
- •Ineligibility for the original SWOG 8710 study
- •Lack of complete blood count with differential prior to first treatment (cystectomy or NAC).
结局指标
主要结局
Overall Survival
时间窗: 26 years
Number of participants who survived at 26 years are reported.
次要结局
未报告次要终点
研究者
研究点 (1)
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