High Amount of Lipid Rich Necrotic Core Lesion Identified by Pre-interventional Intravascular Ultrasound (IVUS) is Associated With High Rate of Delayed Hyper-enhancement as Detected by Contrast-enhanced Cardiac Magnetic Resonance Imaging
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Evaluate the occurrence of new areas of infarction (heart attack) in the heart muscle supplied by the vessel that was treated.
研究概览
简要总结
The purpose of this study is to evaluate whether some features of plaques in coronary arteries predispose the heart muscle to injuries during angioplasty in patients with a narrowing in at least one of the arteries that may need a stent placed during a heart catheterization. Participants undergo a cardiovascular magnetic resonance imaging (MRI) study before the heart catheterization to look for scarring in the heart muscle. During the heart catheterization, participants undergo an intravascular ultrasound (IVUS) exam to look at the make-up of the plaques before the stent placement and the investigators will measure the pressures in the arteries to look at how severe the blockage is. Within 30 days after the heart catheterization, participants will have a second MRI done to look for any new scar in the heart muscle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 to 90 years
- •Patients with known obstrucive coronary arterial disease for PCI in a native coronary artery
- •Ability and willingness to consent and Authorization for use of personal health information (PHI)
- •Ability and willingness to the required follow up procedures
排除标准
- •An acute myocardial infarction in the vascular territory of interest.
- •History of percutaneous coronary intervention in the major epicardial vessel of interest
- •Lesion characteristics that preclude IVUS
- •The presence of delayed enhancement in the territory of the study vessel on baseline CMR
- •Patients with current history of cardiomyopathy which is known to cause enhancement on CMR study
- •Patients who are considered hemodynamically unstable based on clinical assessment by the physician
- •Patients with Class IV congestive heart failure at time of enrollment
- •Patients with poorly controlled hypertension with SBP >/= 210mmhg and/or DBP >/=140 hypertension unable to be treated, at time of enrollment
- •GFR</=30 pre-procedure per institutional standards
- •Patients with any known co-morbid conditions that is limiting their life expectancy to < 1year
- •A known contraindication to Adenosine, including but not limited to:
- •Moderate to severe hyperactive airway disease such as asthma and severe COPD
- •Second or third degree AV block
- •Known sinus node disease, such as sick sinus syndrome or symptomatic bradycardia
- •Known hypersensitivity to Adenosine
- •A known contraindication to MRI
- •Electronically, magnetically, and mechanically activated implants
- •Ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators, and cardiac pacemakers
- •Metallic splinters/fragments in sensitive tissues including the eye, brain, spinal cord etc...
- •Ferromagnetic haemostatic clips in the central nervous system
- •A known contraindication to Gadolinium
- •Patients with history of allergic reactions to gadolinium based contrast
- •Patients with glomerular filtration rate (GFR) </= 30ml/min
- •Inability or unwillingness to consent and Authorization for use of PHI
- •Patients who are unwilling or unable to follow up
- •Known pregnancy
研究组 & 干预措施
All Patients
All patients undergo the same study procedures
干预措施: Cardiac MRI (Other)
结局指标
主要结局
Evaluate the occurrence of new areas of infarction (heart attack) in the heart muscle supplied by the vessel that was treated.
时间窗: 6 months
次要结局
- Evaluate the occurrence of new areas of infarction (heart attack) in the heart muscle supplied by any of the 3 major blood vessels of the heart(6 months)