Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques

Sheba Medical Center1 site in 1 country120 target enrollmentMarch 2001

ConditionsAtherosclerosis Aortic Aneurysm Peripheral Vascular Diseases

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Atherosclerosis
Sponsor: Sheba Medical Center
Enrollment: 120
Locations: 1
Primary Endpoint: To uncover mechanisms of cardiovascular diseases
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Lipid-rich atherosclerotic plaques, or "vulnerable plaques" are prone to rupture, causing local intravascular thrombosis, with subsequent grave clinical consequences. Atherosclerotic plaques normally removed during surgery, and peripheral blood samples will be studied to achieve the following objectives:

"1" Define histological features of the vulnerable plaque, analyze its physical characteristics, and investigate selected gene expression.

"2" Study biomarkers of inflammation in conjunction with the presence of vulnerable plaques.

"3" Explore the potential role of infection in atherogenesis.

Registry

clinicaltrials.gov

Start Date

March 2001

End Date

July 2021

Last Updated

6 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Sheba Medical Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Evidence of symptomatic carotid stenosis exceeding 60%(TIAs or stroke within the last 6 months), and asymptomatic carotid artery stenosis (presenting with progressive carotid stenosis, exceeding 70%)
•Abdominal aortic aneurysm, and aortic occlusive disease
•Peripheral occlusive or aneurysmal disease