NCT00449306Unknown不适用
Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- To uncover mechanisms of cardiovascular diseases
研究概览
简要总结
Lipid-rich atherosclerotic plaques, or "vulnerable plaques" are prone to rupture, causing local intravascular thrombosis, with subsequent grave clinical consequences. Atherosclerotic plaques normally removed during surgery, and peripheral blood samples will be studied to achieve the following objectives:
"1" Define histological features of the vulnerable plaque, analyze its physical characteristics, and investigate selected gene expression.
"2" Study biomarkers of inflammation in conjunction with the presence of vulnerable plaques.
"3" Explore the potential role of infection in atherogenesis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Evidence of symptomatic carotid stenosis exceeding 60%(TIAs or stroke within the last 6 months), and asymptomatic carotid artery stenosis (presenting with progressive carotid stenosis, exceeding 70%)
- •Abdominal aortic aneurysm, and aortic occlusive disease
- •Peripheral occlusive or aneurysmal disease
排除标准
- •Non-compliant patients, incapable of granting approval by informed consent
结局指标
主要结局
To uncover mechanisms of cardiovascular diseases
时间窗: 3 years
次要结局
未报告次要终点
研究者
研究点 (1)
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