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临床试验/NCT04806152
NCT04806152终止不适用

Effect of Exercise on Muscle Mass, Functional Capacity and Physical Activity in Community-dwelling Elderly With Sarcopenia in Jamaica

The University of The West Indies2 个研究点 分布在 1 个国家目标入组 38 人开始时间: 2017年5月2日最近更新:
适应症

试验速览

阶段
不适用
状态
终止
入组人数
38
试验地点
2
主要终点
Lower extremity (LE) functional strength

研究概览

简要总结

This study examined the effects of combined-modality exercise training (resistance, endurance, flexibility and balance) on muscle mass, muscle function and physical activity in community-dwelling elderly living in Jamaica who had been characterised as having sarcopenia.

详细描述

Community-dwelling seniors aged 60 years and older were screened for muscle mass and function (grip strength and walk speed) and persons with sarcopenia were identified using the European Working Group on Sarcopenia in Older Persons (EWGSOP) algorithm for case finding (N=1344). Of the 77 seniors with sarcopenia, 38 consented to participate and were randomly allocated to receive 6 months combined-modality high intensity treadmill based exercise and a 'usual care' home exercise programme. A comparison of the effects of treatment assignment on muscle mass, function, fitness, physical activity level and disability was done. Participants in the supervised combined-modality high intensity group were required to attend sessions 3 times per week; participants in the home exercise programme were required to attend 1 supervised session at the start of their 6-month intervention. Outcomes were assessed at baseline and at the end of the 6-month intervention. Data were analysed using standard statistical parametric and non-parametric methods including repeated measures analysis of variance to determine changes in outcomes and regression to establish determinants of outcomes.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Factorial
主要目的
Treatment
盲法
None

入排标准

年龄范围
60 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • over 60 years old,
  • independently ambulant, with or without an assistive device
  • mentally competent to give informed consent and follow exercise instructions

排除标准

  • a history of stroke with residual disability
  • a diagnosis of cancer
  • neuromuscular disorders
  • auto-immune disorders
  • severe arthritis rendering participation in an exercise programme difficult
  • unstable cardiovascular disease which renders exercise unsafe

结局指标

主要结局

Lower extremity (LE) functional strength

时间窗: 6 months

1-repetition maximum (RM) strength

Appendicular lean mass index

时间窗: 6 months

dual energy x-ray absorptiometry (DEXA) measured appendicular lean mass summed and divided by height squared, expressed in kg/m2

Functional endurance

时间窗: 6 months

Distance walked in 6 minutes

Disability

时间窗: 6 months

Lawton Instrumental Activities of Daily Living scale: minimum score = 0 (low function, dependent); maximum score = 8 (high function, independent). Lower scores indicate a worse outcome.

Fat-free mass

时间窗: 6 months

dual energy x-ray absorptiometry (DEXA) determined: fat mass subtracted from weight, expressed in kg

self-selected walk speed

时间窗: 6 months

speed in the timed-10-metre walk

Accelerometry

时间窗: 6 months

weekly energy expenditure

Balance

时间窗: 6 months

Berg balance test score: minimum score = 0, maximum score = 56. Lower values indicate worse outcome

次要结局

  • Depression(6 months)
  • Timed-up-and-go(6 months)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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