Effects of Resistance Exercise on Muscle Mass, Strength, Body Composition and Heart in Men 30-50 Years Old.
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Sarcopenia
- Sponsor
- University of Erlangen-Nürnberg Medical School
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- fat free Cross Sectional Area (CSA) upper leg
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
A plethora of trials reported the positive effect of resistance exercise on functional and morphological parameters. Although a large amount of the studies used suboptimum devices and obsolete methods the results of these older studies were still considered as golden standard. The aim of the present study is thus to determine the proper effect of different resistance exercise protocols with and without adjuvant protein supplementation on functional and morphological muscle and body composition parameters in male untrained subjects 30-50 years old under special regard of modern medical imaging and segmentation technologies.
Our general study hypothesis is that HIT-resistance exercise significantly impact relevant muscular parameters of the upper leg.
Investigators
Eligibility Criteria
Inclusion Criteria
- •untrained (\< 2 h exercise/week, \< 1 h resistance exercise/week)
- •30-50 years old
Exclusion Criteria
- •medication/diseases affecting intervention or study endpoints
- •history of intense resistance exercise (\> 3 h/week during the last decade)
- •very low physical capacity (\< 100 Watt at ergometry)
- •more than 2 weeks of absence during the interventional period
- •contraindication related to MRI-assessment (i.e. magnetizable intracorporal artefacts)
- •pathological changes of the heart
- •inflammable diseases
Outcomes
Primary Outcomes
fat free Cross Sectional Area (CSA) upper leg
Time Frame: change from baseline in fat free Cross Sectional Area at 5 months
fat free muscle cross sectional area of the upper leg at mid-femur via Quantitative Computed Tomography (QCT)
Secondary Outcomes
- CSA upper leg(change from baseline in CSA upper leg at 5 months)