The Effect of Resistance Training on Muscle Strength and Nutritional Status in Patients With Liver Cirrhosis

University of Aarhus1 site in 1 country39 target enrollmentJanuary 2015

ConditionsLiver Cirrhosis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Liver Cirrhosis
Sponsor: University of Aarhus
Enrollment: 39
Locations: 1
Primary Endpoint: Maximal voluntary muscle strength in knee extensor will be measured by an isokinetic dynamometer and hand strength by hand dynamometer.
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose is to investigate the effect of strength training on muscle strength, muscle mass and nutritional status in patients with liver cirrhosis to clarify possible metabolic and inflammatory changes during this intervention. In addition the investigator examine if the intervention is associated with fewer hospital readmission and an improved quality of life.

Registry

clinicaltrials.gov

Start Date

January 2015

End Date

July 2018

Last Updated

8 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Aarhus

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Cirrhosis, Child Pugh score A and B

Exclusion Criteria

•Cirrhosis, Child-Pugh score C at inclusion
•Neurological and/or psychiatric disorder
•Pregnancy, breastfeeding
•Patients with malignancy
•Patients with hepatic encephalopathy at inclusion
•Patients with atypical diets, such as vegans

Outcomes

Primary Outcomes

Maximal voluntary muscle strength in knee extensor will be measured by an isokinetic dynamometer and hand strength by hand dynamometer.

Time Frame: 12-14 weeks

Secondary Outcomes

Ammonia metabolism as measured by Oral Glutamine Challenge Test(12-14 weeks)
Nutritional status as measured by Triceps skinfold thickness (TSF), mid-upper-arm circumference (MUAC), mid-arm muscle area (MAMA) and hand dynamometer(12-14 weeks)
Readmissions as measured by a follow-up one year after the intervention.(1-1,5 year)
Quality of Life as measured by a standardized questionnaire (SF-36)(12-14 weeks)
Insulin sensitivity as measured by HOMA-IR(12-14 weeks)
Muscle mass as measured by MRi scan and bioimpedance scan.(12-14weeks)