The Effect of Resistance Training on Muscle Strength and Nutritional Status in Patients With Liver Cirrhosis
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- University of Aarhus
- Enrollment
- 39
- Locations
- 2
- Primary Endpoint
- Maximal voluntary muscle strength in knee extensor will be measured by an isokinetic dynamometer and hand strength by hand dynamometer.
Study Overview
Brief Summary
The purpose is to investigate the effect of strength training on muscle strength, muscle mass and nutritional status in patients with liver cirrhosis to clarify possible metabolic and inflammatory changes during this intervention. In addition the investigator examine if the intervention is associated with fewer hospital readmission and an improved quality of life.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Cirrhosis, Child Pugh score A and B
Exclusion Criteria
- •Cirrhosis, Child-Pugh score C at inclusion
- •Neurological and/or psychiatric disorder
- •Pregnancy, breastfeeding
- •Patients with malignancy
- •Patients with hepatic encephalopathy at inclusion
- •Patients with atypical diets, such as vegans
Arms & Interventions
Nutrition
Participants receive a controlled diet consisting of 1.2-1.5 g of protein/kg/day for 12 weeks according to guidelines for enteral nutrition and patients with cirrhosis. The group receives dietary guidance and protein supplements.
Intervention: Nutrition (Behavioral)
Nutrition and strength training
Participants in this group receive same controlled diet consisting of 1.2-1.5 g of protein/kg/day for 12 weeks as the "No intervention"-group. Participants will also receive supervised strength training 3 x 60 min./week for 12 weeks. The group receives dietary guidance and protein supplements, which on training days should be consumed within 30 minutes after exercise.
Intervention: Nutrition and strength training (Behavioral)
Outcomes
Primary Outcomes
Maximal voluntary muscle strength in knee extensor will be measured by an isokinetic dynamometer and hand strength by hand dynamometer.
Time Frame: 12-14 weeks
Secondary Outcomes
- Ammonia metabolism as measured by Oral Glutamine Challenge Test(12-14 weeks)
- Nutritional status as measured by Triceps skinfold thickness (TSF), mid-upper-arm circumference (MUAC), mid-arm muscle area (MAMA) and hand dynamometer(12-14 weeks)
- Readmissions as measured by a follow-up one year after the intervention.(1-1,5 year)
- Quality of Life as measured by a standardized questionnaire (SF-36)(12-14 weeks)
- Insulin sensitivity as measured by HOMA-IR(12-14 weeks)
- Muscle mass as measured by MRi scan and bioimpedance scan.(12-14weeks)