Study on Postoperative Adrenal Function Assessment in Patients With Primary Aldosteronism
- Conditions
- Primary Aldosteronism
- Registration Number
- NCT06534268
- Lead Sponsor
- Ruijin Hospital
- Brief Summary
This study employs a prospective, single-center, open, observational research design to evaluate postoperative adrenal cortical function in patients with primary aldosteronism (PA) and to explore indicators predicting postoperative adrenal insufficiency and their predictive efficacy
- Detailed Description
Patients suspected of having primary aldosteronism and admitted for treatment, who are diagnosed with primary aldosteronism through at least one confirmatory test, and subsequently diagnosed with unilateral primary aldosteronism via bilateral adrenal vein sampling and ACTH stimulation test, will undergo surgery. Those who have an ACTH stimulation test within one week postoperatively will be included in the study.
This study employs a prospective, single-center, open, observational research design to evaluate postoperative adrenal cortical function in patients with primary aldosteronism (PA) and to explore indicators predicting postoperative adrenal insufficiency and their predictive efficacy
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 200
- Patients diagnosed with unilateral primary aldosteronism who undergo surgical treatment and have their cortical function assessed by an ACTH stimulation test within one week postoperatively.
- Patients using medications that affect adrenal cortical function.
- Patients with a history of adrenal surgery
- Pregnant or breastfeeding women
- Patients with severe underlying diseases (such as liver or kidney failure) that may affect adrenal cortical function
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Patients' baseline hormone level 1day serum hormone level
Patients' baseline glucose metabolic levels 1day 0-minute、30-minute、60-minute 、120-minute and 180-minute blood glucose levels after OGTT
Participant's weight and height 1 day BMI(body mess index) in kg/m\^2= (weight in kg) /(height in m)\^2
Number of Participants with baseline glucose metabolic levels 1 day glucose metabolism, lipid metabolism, liver and kidney function, electrolytes, etc
Number of Participants with baseline lipid metabolic levels 1day blood lipid levels
The gender and age of the participants 1 day age in years and sex (female or male) of patients
Patients' hormone levels at 0 minutes and 120 minutes after preoperative ACTH stimulation test 1day cortisol and aldosterone levels
Number of Participants with baseline electrolytes levels 1day sodium, potassium, chloride, calcium, and phosphorus ion levels
Patients' hormone levels at 0 minutes and 120 minutes after postoperative ACTH stimulation test 1day cortisol and aldosterone levels
Number of Participants with baseline kidney function levels 1day Creatinine, blood urea nitrogen (BUN), and uric acid levels
- Secondary Outcome Measures
Name Time Method Number of Participants with changes of lipid metabolic levels after surgical management 1day blood lipid levels
the changes of glucose metabolic levels after surgical management 1day 0-minute、30-minute、60-minute 、120-minute and 180-minute blood glucose levels after OGTT
the changes of hormone levels after surgical management 1day cortisol and aldosterone serum hormone level
Number of Participants with changes of kidney function levels after surgical management 1 day Creatinine, blood urea nitrogen (BUN), and uric acid levels