The Lipid Profile of the Skin Surface in Acne

Completed

• Conditions: Acne
• Interventions: Drug: Tretinoin or Adapalene; Drug: Isotretinoin

• Registration Number: NCT02180425
• Lead Sponsor: University of California, Davis

Brief Summary

The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.

Detailed Description

Skin lipid profile will be conducted via sebutapes- adhesive tapes that painlessly absorbs sebum from the face. These tapes will be placed on the face for 1 hour. A photograph of the face will be taken during each study visit. A sebumeter will also be used to measure skin sebum secretion rate.

Study Timeline

• Study Start: 2013-11
• Study First Submitted: 2014-06-30
• Study First Submitted QC: 2014-06-30
• Study First Posted: 2014-07-02
• Primary Completion: 2015-05
• Study Completion: 2015-07
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-25
• Last Update Posted: 2017-05-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• age 12 to 30 years
• have been prescribed tretinoin OR isotretinoin

Exclusion Criteria

• those who have taken isotretinoin (systemic)
• those who used tretinoin or other topical retinoid within two weeks of starting the study
• those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome
• those who are pregnant, prisoners, or cognitively impaired
• those who do not fit the inclusion criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Acne Group, Topical Retinoid	Tretinoin or Adapalene	These subjects have been prescribed a topical retinoid for their acne. They will participate in the study for a period of 1 month.
Acne Group, Isotretinoin	Isotretinoin	These subjects have been prescribed isotretinoin for their acne. They will participate in the study for a period of 5-6 months.

Primary Outcome Measures

Name	Time	Method
Skin lipid profile of acne and healthy patients	baseline visit	Compare the skin lipid profile of acne and healthy patients at baseline

Secondary Outcome Measures

Name	Time	Method
Skin lipid profile of acne patients after treatment	at 1 month and 4-5 months of treatment	Patients in the topical retinoid group will have their lipids evaluated after 1 month of treatment. Patients in the systemic retinoid (isotretinoin) group will have their lipids evaluated after 1 and 4-5 months of treatment.

Trial Locations

Locations (2)

UC Davis Department of Dermatology; 🇺🇸 Sacramento, California, United States

Dermatology Research Area; 🇺🇸 Davis, California, United States